J Gastroenterology: 脾切除术后胃反流或胃囊静脉曲张行逆行静脉闭塞的治疗结果

2020-06-22 MedSci原创 MedSci原创

尽管临床上通常选择球囊闭塞逆行静脉闭塞术(BRTO)来治疗门静脉高压引起的胃静脉曲张,但将BRTO和脾切除术与胃血运重建术(Sp + Dev)进行比较的数据仍然有限。因此,本项研究旨在进行二者之间的相

背景:

尽管临床上通常选择球囊闭塞逆行静脉闭塞术(BRTO)来治疗门静脉高压引起的胃静脉曲张,但将BRTO和脾切除术与胃血运重建术(Sp + Dev)进行比较的数据仍然有限。因此,本项研究旨在进行二者之间的相关研究。

方法:

从2009年1月至2018年2月,研究人员共 纳入100例接受Sp + Dev(n  = 45)或BRTO(n = 55)的门静脉高压引起的胃静脉曲张患者。使用治疗加权调整后的对数秩检验的总生存期(OS)和再出血率进行了计算,并通过Cox回归分析确定独立的危险因素。分析手术后的肝功能变化和不良事件。

结果:

Sp + Dev组的患者血小板计数往往低于BRTO组,但这些组之间的肝功能没有差异。Sp + Dev和BRTO组的5年OS率分别为73.4%和50.0%(p  = 0.005)。两组之间的再出血率无显着差异。多因素分析显示,血清白蛋白水平≤3.6g / dL,凝血酶原时间活性(PT%)≤80%,血清肌酐水平≥0.84mg / dL是不良的预后因素。尽管Sp + Dev组术后有短期并发症,但Sp + Dev组比BRTO组更能有效改善肝功能。

结论

与BRTO相比,Sp + Dev在治疗门静脉高压引起的胃静脉曲张方面表现出更好的OS和肝功能改善。

原始出处:

Ko Oshita. Et al. Treatment outcomes after splenectomy with gastric devascularization or balloon-occluded retrograde transvenous obliteration for gastric varices: a propensity score-weighted analysis from a single institution. J Gastroenterology.2020.

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    2020-10-24 许安
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2020, time=2020-06-24, status=1, ipAttribution=)]
  5. 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channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85288, encryptionId=2caa85288af, topicName=脾切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d0224012521, createdName=lixiaol, createdTime=Tue Dec 22 16:35:12 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1505020, encodeId=2138150502061, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Wed Jun 24 06:35:12 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535940, encodeId=ded6153594091, content=<a href='/topic/show?id=ae716469300' target=_blank style='color:#2F92EE;'>#治疗结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64693, encryptionId=ae716469300, topicName=治疗结果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Jun 24 06:35:12 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571690, encodeId=4f0e15e169043, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Wed Jun 24 06:35:12 CST 2020, time=2020-06-24, status=1, ipAttribution=)]
    2020-08-17 fusion
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  7. 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    2020-06-24 feifers

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