Obesity:怀孕让肥胖女性更健康

2015-04-15 Mechront 译 MedSci原创

众所周知,超重/肥胖人群的心血管疾病罹患风险会增加,但是这群人中,对于育龄期女性,怀孕这个特殊神圣的过程能否让其风险发生改变呢?Niemczyk NA等人在超重/肥胖的育龄期女性中进行了一项研究,以探究亚临床心血管疾病(CVD)与产次的关系。

众所周知,超重/肥胖人群的心血管疾病罹患风险会增加,但是这群人中,对于育龄期女性,怀孕这个特殊神圣的过程能否让其风险发生改变呢?Niemczyk NA等人在超重/肥胖的育龄期女性中进行了一项研究,以探究亚临床心血管疾病(CVD)与产次的关系。

该研究共获得了191名超重/肥胖(BMI 25-39.9 kg/m2 )年轻女性的生育史资料,并且研究者通过B超获得了参与者颈动脉内膜中层厚度(IMT)、颈动脉外膜直径(IAD)等数据资料。根据人口统计学资料、心血管疾病危险因素、产次相关风险因素校正后,通过线性回归模型评估颈动脉测量值和产次间的联系。

研究结果显示,与生育过的女性(n = 102, 年龄39.5 ± 4.9岁)相比,未生育过的女性(n = 70, 年龄34.9 ± 7.1岁),其颈动脉外膜直径(IAD)增加 (0.230 mm, SE 0.08, P = 0.003),颈动脉内膜中层厚度(IMT) 增加(0.031 mm, SE 0.01, P = 0.007)。根据年龄、种族、CVD风险因素校正后,两组间该差异性仍存在。

研究结果表明,对于纳入的25-45岁超重和肥胖育龄期女性,未生育过的女性更可能有颈动脉不健康的标志(提示亚临床心血管疾病)。该研究同时暗示怀孕或许可以使超重/肥胖的育龄期女性整体更健康,也是怀孕对其的益处之一。

原始出处:

Niemczyk NA1, Catov JM, Barinas-Mitchell E, McClure CK, Roberts JM, Tepper PG, Sutton-Tyrrell K.Nulliparity is associated with less healthy markers of subclinical cardiovascular disease in young women with overweight and obesity.Obesity (Silver Spring). 2015 Apr 10. doi: 10.1002/oby.21044. [Epub ahead of print]

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    2016-03-12 智慧医人
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    2015-04-17 lingaifan
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    2015-04-17 skhzy

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