Int J Cardiol:代谢综合征和糖尿病对钙化性主动脉瓣狭窄进展的影响!

2017-07-03 xing.T MedSci原创

在该主动脉狭窄患者的前瞻性队列中,没有发现代谢综合征或糖尿病对AS进展的影响。尽管代谢综合征和糖尿病应该积极治疗,但不应影响AS进展。我们的研究结果支持这一理论,即如果心血管疾病的危险因素可能在AS发病早期起作用,但它们对进展没有或没有影响。

主动脉狭窄进展的决定因素尚不清楚,代谢综合征糖尿病被认为起到了积极的推动作用,但相应的文献匮乏,结果相互矛盾。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员试图通过一个正在至少为轻度主动脉狭窄的无症状患者进行的前瞻性队列进行评估它们的影响。

研究人员招募了203例患者(73±9岁,男性占75%),至少随访2 年。在基线时进行危险因素评估,平均压力梯度(MPG)和主动脉瓣钙化程度(AVC)指标的年度进展计算为[(最终-基线测量)/随访时间]。

99例(49%)患者有代谢综合征,50例(25%)患者有糖尿病(包括39例代谢综合征)。随访3.2±1.2年后,主动脉瓣钙化进展在有和无代谢综合征的患者之间没有差异,无论是MPG(+3±3 vs. +4±4mmHg/年,P=0.25)或AVC(+211±231 vs. +225±222AU/年,P=0.75)。在糖尿病患者中也得到了相同的结果(3±3 vs. 4±4mm/年,P=0.53,187±140 vs. 229±248AU/年,P=0.99)。根据年龄、他汀类药物处方、瓣膜解剖和主动脉瓣狭窄严重程度的所有亚组中,代谢综合征对主动脉狭窄都没有影响(P均≥0.10)。

在该主动脉狭窄患者的前瞻性队列中,没有发现代谢综合征或糖尿病对AS进展的影响。尽管代谢综合征和糖尿病应该积极治疗,但不应影响AS进展。我们的研究结果支持这一理论,即如果心血管疾病的危险因素可能在AS发病早期起作用,但它们对进展没有或没有影响。

原始出处:

Ariane Testuz,et al. Influence of Metabolic Syndrome and Diabetes on Progression of Calcific Aortic Valve Stenosis. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2017.06.104

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    2018-04-21 venlin
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近日,国际杂志 《Diabetic medicine》上在线发表一项关于西澳大利亚79-97岁糖尿病男性的健康状况,目的在于调查与老年男性糖尿病相关的行为,生理和生化特征。 研究人员对西澳大利亚珀斯的79-97岁的社区居民进行横断面分析。评估了生活方式行为,自我评估健康,生理功能,空腹血糖和HbA 1c水平。