Stroke:脑静脉血栓形成后发生肺栓塞的风险如何?

2017-02-23 xing.T MedSci原创

由此可见,CVT后发生PE的风险明显低于DV后发生PE的风险。在CVT患者中,住院期间发生PE的风险最大。

静脉血栓形成(CVT)是一种静脉血栓栓塞类型。CVT后发生肺栓塞(PE)的风险是否与深静脉血栓形成(DVT)后发生PE的风险相类似仍是未知。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估了CVT后发生PE的风险。

研究人员采用在2005年至2013年期间在美国加利福尼亚、纽约和佛罗里达所有急诊科就诊和住院的行政数据进行了一项回顾性队列研究。研究人员使用之前证实的国际疾病分类第九修订版临床编码确定了CVT或DVT和PE结局。采用Kaplan-Meier生存统计和Cox比例风险模型比较CVT 后发生PE风险与DVT后发生PE的风险。

研究人员确定了4754例CVT患者和241276DVT患者。在平均随访3.4(±2.4)年期间,138例CVT患者和23063例DVT患者发生PE。相比于DVT患者,CVT患者更年轻,更常见于女性,并且血栓栓塞的危险因素更少。住院期间,CVT患者发生PE的发生率为1.4%(95%可信区间[CI]为1.1%-1.8%),而DVT患者发生PE的发生率为6.6%(95%CI为6.5%-6.7%)。到5年后,CVT患者发生PE的累积发生率为3.4%(95%CI为2.9%-4%),而DVT患者为10.9%(95%CI为10.8%-11.0%;P<0.001)。相比于DVT,CVT与较低的PE调整风险比更相关(风险比为0.26;95%CI为0.22-0.31)。

由此可见,CVT后发生PE的风险明显低于DV后发生PE的风险。在CVT患者中,住院期间发生PE的风险最大。       

原始出处:


Ava L. Liberman, et al. Risk of Pulmonary Embolism After Cerebral Venous Thrombosis.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.116.016316

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    2017-07-22 fusion
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    2017-04-26 xue8602
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    2017-02-24 dachengl

    不知抗凝治疗的偏倚有无在文章中讨论

    0

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