Crit Care:重症监护病房中对抗生素使用和感染诊断的全方位概述

2018-10-03 xing.T MedSci原创

由此可见,通过前瞻性地结合抗生素、微生物学和临床数据,研究人员能够构建关于抗生素使用和感染诊断的纵向、多方面的数据集。这种完整的概述可以确定未来抗生素管理需要注意的抗生素处方模式。

准备抗生素管理计划需要掌握有关整体抗生素使用、处方指征和生态学的详细信息。然而,这种纵向数据很少。患者病例的电子化提供了收集高质量的完整数据的潜力。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,为了深入了解全球抗生素使用情况,研究人员的目标是在很长一段时间内从不同角度探索重症监护室(ICU)的抗生素处方情况。

研究人员分析了从2013年1月1日至2016年12月31日期间入住根特大学医院ICU的所有成年患者。ICU医生在日常工作流程中通过专用软件将抗生素处方数据前瞻性地与诊断(疑似部位、处方或预防时的感染严重程度和概率)和微生物学数据合并。感染的明确部位和感染概率(分类为高/中/低)由专门的ICU医师在患者出院时重新评估。

在研究期间,8763名患者入院,总体抗生素消耗达1232天治疗(DOT)/1000患者天数。抗菌DOT(总DOT的84%)与80%的感染相关;主要病灶是呼吸道(49%)和腹部(19%)。在56%(3169/5686)的病例中发现了微生物感染。中度/低概率感染占呼吸道感染抗菌处方DOT的42%;对于腹部感染,这个数字是15%。中度/低度概率呼吸道感染的中位治疗持续时间为4天(IQR为3-7)。抗真菌DOT(总DOT的16%)与47%的总抗真菌DOT感染有关。抗真菌预防主要用于外科ICU中(76%),中位持续时间为4DOT(IQR为2-9)。

由此可见,通过前瞻性地结合抗生素、微生物学和临床数据,研究人员能够构建关于抗生素使用和感染诊断的纵向、多方面的数据集。这种完整的概述可以确定未来抗生素管理需要注意的抗生素处方模式。

原始出处:

Liesbet De Bus.et al.A complete and multifaceted overview of antibiotic use and infection diagnosis in the intensive care unit: results from a prospective four-year registration.Critical Care.2018.https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-2178-7

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    2018-11-28 jyzxjiangqin

    重症监护室对健康生活方式。

    0

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    2018-11-14 jyzxjiangqin

    重症监护室对健康老年人的治疗。

    0

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    2018-11-03 jyzxjiangqin

    重症监护室对健康体重的治疗。

    0

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    2018-10-20 jyzxjiangqin

    重症监护病房中抗生素使用。

    0

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    2018-10-11 jyzxjiangqin

    重症监护室对抗生素使用的影响。

    0

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    2018-10-05 明月清辉

    谢谢分享,学习了

    0

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    2018-10-04 zhouqu_8

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