Ann Intern Med:强直性脊柱炎可增加患者心血管和脑血管疾病的死亡率

2015-08-19 sunshine 译 MedSci原创

Ann Intern Med:强直性脊柱炎或可增加患者心血管和脑血管疾病的死亡率近日有研究表明,强直性脊柱炎可增加心血管或脑血管疾病死亡率的风险,该研究成果于2015年8月11日在线发表于Ann Intern Med。强直性脊柱炎(AS)是一种主要侵犯于年轻人脊柱的慢性炎症性关节炎,既往研究表明强直性脊柱炎可增加心血管及脑血管疾病死亡率。本研究以人群为基础,采用回顾性队列研究分析研究加拿大的健康管



近日有研究表明,强直性脊柱炎可增加心血管或脑血管疾病死亡率的风险,该研究成果于2015年8月11日在线发表于Ann Intern Med

强直性脊柱炎(AS)是一种主要侵犯于年轻人脊柱的慢性炎症性关节炎,既往研究表明强直性脊柱炎可增加心血管及脑血管疾病死亡率。

本研究以人群为基础,采用回顾性队列研究分析研究加拿大的健康管理数据,以确定强直性脊柱炎是否可增加心血管及脑血管疾病的死亡率。

研究共分析了21473名15岁以上的AS患者以及86606名健康对照者,匹配了年龄、性别以及居住地。调查评估了所有研究对象的心血管及脑血管疾病死亡率的结果,计算了血管疾病死亡的危险比(HRs),校正了患癌史、糖尿病史、老年痴呆症史、炎症性肠炎史、高血压史、慢性肾病史以及周围血管病史,对于66岁以上的人群还校正了相关的用药史。确定了AS患者血管疾病死亡的独立危险因素。

结果发现,AS患者的平均年龄为46岁,53%为男性。分别对166920名AS患者及686461名健康对照者进行随访。校正后AS患者血管疾病死亡的总HRs为1.36(95% CI为1.13-1.65),男性HRs为1.46 (95% CI为1.13 -1.87),女性HRs为1.24 (95% CI为0.92 -1.67)。年龄,性别,低收入,痴呆,慢性肾病以及外周血管疾病均为血管疾病死亡的高危因素。此外,65岁及以上的老人未服用非甾体类抗炎药及他汀类药物也为血管疾病死亡的高危因素。

总而言之,强直性脊柱炎与血管疾病死亡风险的增加确有关联。因此,有必要制定出可筛查并治疗AS患者可干预的血管疾病死亡危险因素的一个全面的策略。

原始出处:

Nisha Nigil Haroon, MD, DM, DNB, MSc; J. Michael Paterson, MSc; Ping Li, PhD; Robert D. Inman, MD; and Nigil Haroon, MD, PhD, DM.Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-based Study.Ann Intern Med.  11 August 2015 doi:10.7326/M14-2470

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    2016-05-26 zywlvao
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强直性脊柱炎(AnkylosingSpondylitis,AS)是一种慢性炎症性疾病,主要侵犯骶髂关节、脊柱骨突、脊柱旁软组织及外周关节,引起炎性疼痛、晨僵、活动受限等症状,严重者可出现关节强直。同时可伴发关节外表现,包括眼葡萄膜炎、肠道炎症、指/趾炎、皮疹等,通常为单独出现或重叠存在,其中以眼和肠道的病变最为常见。根据累及部位和临床表现的不同,可将AS分为以脊柱关节受累为主的中轴型和以外周关节受

Ann Rheum Dis:强直性脊柱炎病情越重脊柱影像学进展越明显

近年来,强直性脊柱炎(AS)患者的炎症程度与其脊柱新骨形成之间的相关性被广泛讨论。肿瘤坏死抑制剂(TNFi)治疗对控制患者的病情活动度有效,然而却无法抑制影像学破坏的进展。为分析 AS 患者的病情活动度与影像学病情进展之间的长期相关性,来自荷兰阿姆斯特丹大学临床风湿免疫专业的 Sofia Ramiro 博士等人对 AS 国际研究项目(OASIS)的研究结果进行纵向队列分析。

强直性脊柱炎引起的颈椎骨折1例

2014年9月30日,Neurology杂志刊登了如下一则病例报道。 患者男性,53岁,因患强直性脊柱炎(AS)而运动缓慢。近来,患者出现昏迷、瘫痪。查体:咳嗽反射、呕吐反射消失,角膜反射、瞳孔反射存在。 脊柱CT扫描(见下图)示第2颈椎骨折,严重损伤颈髓,脊柱关节僵硬。该患者血流动力学不稳定,患者家属已决定放弃积极治疗。 强直性脊柱炎是一种主要侵犯脊柱的慢性进行性炎性疾病,

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由第二军医大学骨关节炎专病中心、第二军医大学附属长海医院关节骨病外科主办的第七届长海关节外科大会暨首届上海强直性脊柱炎研究焦点论坛于2014年12月13日在沪成功召开。 与会嘉宾合影 目前国内每年举办关节外科会议使得最新的关节外科治疗技术、人工关节技术与方法、理念、人工关节假体设计思路、产品、围手术期相关问题等新知识、新理论、新进展能够及时地得到传播与应用,使我国关节外科水