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J Bone Miner Res：MiR-27a靶向DKK2和SFRP1以促进种植体周围炎骨缺损区的骨再生

2018-09-02 MedSci MedSci原创

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种植体周围炎的炎症微环境中，植入物表面的有限的骨生成阻碍了使用当前临床疗法进行骨再整合。微小RNA（miRNA）可作为有效的分子管理器，可同时调节多种内源性过程，如炎症和成骨。 miRNA的递送可以提供某些疾病的有效治疗方法。在这项工作中，我们发现miR-27a在犬种植体周围炎模型的样本中差异性下调。我们发现，在体外，过表达miR-27a通过改善TNF-α对骨形成的抑制来正向调节成骨-血管生成偶联

种植体周围炎的炎症微环境中，植入物表面的有限的骨生成阻碍了使用当前临床疗法进行骨再整合。微小RNA（miRNA）可作为有效的分子管理器，可同时调节多种内源性过程，如炎症和成骨。 miRNA的递送可以提供某些疾病的有效治疗方法。在这项工作中，我们发现miR-27a在犬种植体周围炎模型的样本中差异性下调。

我们发现，在体外，过表达miR-27a通过改善TNF-α对骨形成的抑制来正向调节成骨-血管生成偶联。机制上，我们将Dickkopf2（DKK2）和分泌的卷曲相关蛋白（SFRP1）鉴定为成骨和血管生成的两个必需的直接miR-27a靶标。此外，我们构建了miR-27a增强的输送系统，以修复犬种植体周围炎模型中植入物周围的骨缺损。

综上所述，该研究结果表明，miR-27a处理组可以优化体内新骨形成和再合并。我们的分析证明该策略对种植体周围炎具有治疗效果，表明它是维持牙种植体稳定性和咀嚼功能的可行方法。

原始出处：

Wu X, Gu Q, et al., MiR-27a targets DKK2 and SFRP1 to promote reosseointegration in the regenerative treatment of peri-implantitis. J Bone Miner Res. 2018 Aug 27. doi: 10.1002/jbmr.3575.

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    2019-02-25 apoenzyme

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    2019-05-09 huangdf

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    2019-06-15 smallant2002

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    2018-09-04 仁心济世

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    2018-09-04 lfcmxl

    #骨缺损#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1915185, encodeId=d7b2191518579, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Mon Feb 25 03:15:00 CST 2019, time=2019-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701969, encodeId=085b1e019696a, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Thu May 09 03:15:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930643, encodeId=bf921930643bf, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sat Jun 15 14:15:00 CST 2019, time=2019-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343812, encodeId=16e71343812c9, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Sep 04 07:15:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419269, encodeId=9e35141926920, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Tue Sep 04 07:15:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472150, encodeId=251714e215066, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Sep 04 07:15:00 CST 2018, time=2018-09-04, status=1, ipAttribution=)]
    2018-09-04 lsj630

    #骨再生#

    0