J Invest Derm：非甾体类抗炎药（NSAIDs）可能预防皮肤癌

2014-12-20 MedSci MedSci原创译

据一项最新研究表明非甾体类抗炎药（NSAIDs）能够预防皮肤癌，该研究发表于近日的Journal of Investigative Dermatology上。NSAID可以降低大肠癌、肺癌、乳腺癌和前列腺癌的发病风险，但是还没有证据表明它能够预防皮肤癌。Chiho Muranushi及其同事根据已发表的文献进行了meta分析，研究了阿司匹林、非阿司匹林类NSAIDs以及其他NSAIDs类药物对鳞状

据一项最新研究表明非甾体类抗炎药（NSAIDs）能够预防皮肤癌，该研究发表于近日的Journal of Investigative Dermatology上。NSAID可以降低大肠癌、肺癌、乳腺癌和前列腺癌的发病风险，但是还没有证据表明它能够预防皮肤癌。Chiho Muranushi及其同事根据已发表的文献进行了meta分析，研究了阿司匹林、非阿司匹林类NSAIDs以及其他NSAIDs类药物对鳞状细胞癌（SCC）的预防作用。肤色浅的人种容易患SCC。NSAIDs可以抑制COX-2，而COX-2催化炎症因子前列腺素E2的合成。在长期紫外线的照射下，COX-2可以在SCC患者中过表达。研究者纳入了9篇文献，其中5篇是病例对照，3篇队列研究，以及一篇随机对照研究。meta分析结果表明，与不使用NSAIDs类药物的人相比，使用非阿司匹林类NSAIDs和其他类型NSAIDs的人其SCC发病率低。尤其是对于有过光化性皮肤肿瘤病史或角化细胞肿瘤的患者，NSAIDs的作用更为显著。使用阿司匹林的人其SCC的患病风险下降，但是数据结果不显著。只有随机对照实验表明阿司匹林的作用呈剂量依赖性。研究者认为，非

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2015-06-20 d830372

#SAID#

27 0
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2015-01-07 xiangyuzhou971

#EST#

21 0
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2015-07-22 wjywjy

#AID#

19 0
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2014-12-22 zhouqu_8

#非甾体类抗炎药#

29 0
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2014-12-22 ms6390871039024434

#NSAIDs#

46 0
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2014-12-22 xinmeili

#抗炎药#

26 0
[GetPortalCommentsPageByObjectIdResponse(id=1793570, encodeId=35791e93570c1, content=<a href='/topic/show?id=0a3c158509b' target=_blank style='color:#2F92EE;'>#SAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15850, encryptionId=0a3c158509b, topicName=SAID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a244, createdName=d830372, createdTime=Sat Jun 20 17:54:00 CST 2015, time=2015-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050428, encodeId=4ff92050428b2, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Jan 07 16:54:00 CST 2015, time=2015-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033814, encodeId=bcd22033814f3, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Wed Jul 22 00:54:00 CST 2015, time=2015-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314368, encodeId=b0e1131436804, content=<a href='/topic/show?id=13669956408' target=_blank style='color:#2F92EE;'>#非甾体类抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99564, encryptionId=13669956408, topicName=非甾体类抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Dec 22 01:54:00 CST 2014, time=2014-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323163, encodeId=5a461323163c9, content=<a href='/topic/show?id=ee9b13065da' target=_blank style='color:#2F92EE;'>#NSAIDs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13065, encryptionId=ee9b13065da, topicName=NSAIDs)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Mon Dec 22 01:54:00 CST 2014, time=2014-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346713, encodeId=ba6b1346e135f, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Mon Dec 22 01:54:00 CST 2014, time=2014-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365607, encodeId=8f1d136560ec6, content=<a href='/topic/show?id=41fa21e036' target=_blank style='color:#2F92EE;'>#AIDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2170, encryptionId=41fa21e036, topicName=AIDS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbcc223, createdName=cooco, createdTime=Mon Dec 22 01:54:00 CST 2014, time=2014-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413624, encodeId=74b014136244a, content=<a href='/topic/show?id=9209130645d' target=_blank style='color:#2F92EE;'>#NSAID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13064, encryptionId=9209130645d, topicName=NSAID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80342986042, createdName=amyloid, createdTime=Mon Dec 22 01:54:00 CST 2014, time=2014-12-22, status=1, ipAttribution=)]
2014-12-22 cooco

#AIDS#

24 0
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2014-12-22 amyloid

#NSAID#

35 0

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