Alzheimers Res Ther:中年时的体重指数与血浆Aβ异常折叠呈负相关

2021-09-03 Nebula MedSci原创

中年时的体重指数与血浆Aβ异常折叠呈负相关

评估阿尔茨海默病风险因素与早期病理变化之间的关联,有助于揭示阿尔茨海默病早期干预和预防措施的潜力。该研究目的是明确阿尔茨海默病临床综合征(临床 AD)的风险因素,如体重指数(BMI),是否与血液中的 Aβ 错误折叠(老年人 AD 风险的一个重要标志)有关

ESTHER 研究是一项基于人群的德国老年人(50-75 岁)队列研究,在基线时收集了受试者有关风险因素的信息和血液样本。使用免疫红外传感器对分析了共 872 名受试者的血浆 Aβ 错误折叠,这些受试者来自痴呆症病例和匹配对照的嵌套病例对照研究队列。通过多元逻辑回归评估风险因素与 Aβ 错误折叠之间的关联。并在 5987 名队列受试者中平行调查了 17 年随访期间风险因素与 AD 发病率之间的关联,以进行比较。

(A)有无Aβ错误折叠的受试者的BMI变化; (B)有无临床AD的受试者的BMI变化

根据报告的历史体重,50 岁时的 BMI 与 Aβ 错误折叠呈负相关 (aOR 0.64, 95% CI 0.43-0.96, p=0.03)。基线和 40 岁时的 BMI 具有相似的相关性,但无统计学意义。对于其他风险因素,如糖尿病、吸烟和体育锻炼等,未发现与 Aβ 错误折叠具有统计学意义的相关性。另一方面,与缺乏身体活动相比,低水平的身体活动与发生临床 AD 的风险显著降低相关。

该研究结果支持在 AD 临床确诊前多年即可检测到 AD 病变;AD 病变可能与中年时的体重变化相关。此外,低水平的身体活动或能显著降低 AD 症状发作的风险。

原始出处:

Möllers Tobias,Stocker Hannah,Perna Laura et al. Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood.Alzheimers Res Ther, 2021, 13: 145. https://doi.org/10.1186/s13195-021-00889-2

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    2021-11-07 anminleiryan
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    2021-09-05 hmwwww
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    2021-09-05 膀胱癌

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