ASCO 2020:特瑞普利单抗9项研究成果亮相ASCO大会

2020-05-01 君实医学 君实医学

今年的ASCO大会主题为“Same Great Science,New Virtual Format(科学依然博大精深,新虚拟格局蓄势待发)”。在这个特定的非常时期,ASCO将

今年的ASCO大会主题为“Same Great Science,New Virtual Format(科学依然博大精深,新虚拟格局蓄势待发)”。在这个特定的非常时期,ASCO将依然致力于呈现更多重要研究发现和临床数据成果,以此平台与来自世界各地的肿瘤学者及研究者分享肿瘤领域内最新的学术成果和更优化的诊疗方案。

同时,来自我国多个顶尖肿瘤医学团队针对特瑞普利单抗治疗的有效性与安全性的研究结果的更新也如约而至。这也是君实生物连续第3年在国际性权威会议上汇报特瑞普利单抗的研究进展。

Overall survival and biomarker analysis of a phase Ib combination study of Toripalimab, a humanized IgG4 mAb against programmed death-1 (PD-1) with axitinib in patients with metastatic mucosal melanoma.

一项探索特瑞普利单抗联合阿昔替尼治疗转移性黏膜黑色素瘤患者的Ib期临床研究的总生存期和生物标志物分析

Abstract #10007

汇报板块:Oral abstract session

 

Recombinant humanized anti-PD-1 monoclonal antibody toripalimab in patients with metastatic urothelial carcinoma: results of an open-label phase II clinical study POLARIS-03.

特瑞普利单抗治疗转移性尿路上皮癌患者:一项开放性II期临床研究POLARIS-03的研究结果

Abstract #5040

汇报板块:Poster Session  #109

 

Clinical response and biomarker analysis of POLARIS-02 a Phase II study of toripalimab, a humanized IgG4 mAb against programmed death-1 (PD-1) in patients with metastatic nasopharyngeal carcinoma.

一项探索特瑞普利单抗治疗转移性鼻咽癌患者的II期临床研究POLARIS-02的临床应答及生物标志物分析

Abstract #6542

汇报板块:Poster Session  #203

 

An exploratory study of sorafenib plus toripalimab for unresectable hepatocellular carcinoma with portal vein tumor thrombus.

一项索拉非尼联合特瑞普利单抗治疗不可切除肝细胞癌合并门静脉癌栓患者的探索性研究

Abstract  #TPS4658

汇报板块:Poster Session  #266

 

A phase II study of vorolanib (CM082) in combination with toripalimab (JS001) in patients with advanced mucosal melanoma.

一项vorolanib(CM082)联合特瑞普利单抗治疗晚期黏膜黑色素瘤患者的II期研究

Abstract  #10040

汇报板块:Poster Session  #389

 

Clinical response and biomarker analysis of a phase II basket trial of toripalimab, a PD-1 mAb in combination with standard chemotherapy as a first-line treatment for patients with solid tumors.

一项探索特瑞普利单抗联合标准化疗一线治疗实体瘤患者的II期篮式研究的临床应答和生物标志物分析

Abstract  #e15083

汇报板块:Publication Only

 

 Hepatic artery infusion chemotherapy combined with apatinib and toripalimab in advanced hepatocellular carcinoma: Real-world data from a single center.

肝动脉灌注化疗联合阿帕替尼和特瑞普利单抗治疗晚期肝细胞癌:来自单中心的真实世界数据

Abstract  #e16602

汇报板块:Publication Only

 

Combined recombinant humanized anti-PD-1 monoclonal antibody (JS001) and nab-paclitaxel/gemcitabine (AG) as the first-line therapy for patients with advanced pancreatic adenocarcinoma: Preliminary results of an open-label, phase Ib/II clinical study.

重组人源化抗PD-1单克隆抗体(JS001)联合白蛋白紫杉醇/吉西他滨(AG)作为晚期胰腺腺癌患者的一线治疗:一项开放标签、Ib / II期临床研究的初步结果

Abstract  #e16792

汇报板块:Publication Only

 

A multi-center phase II study of toripalimab with chemotherapy in patients with EGFR mutant advanced NSCLC patients resistant to EGFR TKIs: Efficacy and biomarker analysis.

一项探索特瑞普利单抗联合化疗治疗EGFR-TKI治疗失败的EGFR突变的晚期NSCLC患者的多中心、Ⅱ期研究的疗效和生物标志物分析

Abstract  #e21618

汇报板块:Publication Only

关于特瑞普利单抗

国家药监局(NMPA)已受理特瑞普利单抗(商品名为拓益)用于治疗既往接受过二线及以上系统治疗失败的复发/转移性鼻咽癌(NPC)患者的新适应症上市申请,这也是全球首个抗PD-1单抗治疗复发/转移性鼻咽癌的新药上市申请。

2020年美国癌症研究协会(AACR)年会由线下转为线上,于4月27日-28日和6月22日-24日分两次举办。会议期间,北京大学肿瘤医院陆明教授代表其研究团队公布了和黄医药自主研发的口服酪氨酸激酶抑制剂(TKI)索凡替尼(surufatinib)联合特瑞普利单抗(toripalimab,针对PD-1的人源化lgG4型单克隆抗体)治疗晚期实体瘤的Ⅰ期临床研究结果(Abstract # 9563)。

 

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    2021-01-16 quxin068
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    2020-05-01 qingfengqishi5

    学习了,学习了

    0

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特瑞普利单抗多项研究在ASCO大会亮相,展现中国力量

世界上规模最大,学术水平最高,最具权威的临床肿瘤学会议——美国临床肿瘤学会(ASCO)年会于美国芝加哥召开。今年的主题为“Caring for Every Patient,Learning from Every Patient”。在2019年ASCO年会上,中国首个上市的国产PD-1单抗特瑞普利单抗(Toripalimab,拓益)展现风采,多项研究结果在大会展示,为全球抗肿瘤研究贡献中国力量。

病例:特瑞普利单抗联合化疗新辅助治疗获PR,初始手术困难的食管鳞癌患者成功施行根治术

免疫治疗在食管癌中进展迅速,已在晚期食管癌患者的二线及以上治疗中表现出较化疗更优的生存结果。其在食管癌一线治疗中的研究也有多项在进行中。不仅如此,鉴于免疫治疗的治疗潜力,其与化疗、化放疗联合用于可切除食管癌新辅助治疗的研究也取得了初步成果,为局部晚期的患者带来了获益可能。本文介绍的这例食管癌患者,初始手术切除有困难,经PD-1单抗特瑞普利单抗联合化疗新辅助治疗后,原发灶明显缩小,得以成功实施根治性

君实生物特瑞普利单抗联合阿昔替尼治疗黏膜黑色素瘤获得美国FDA孤儿药资格认定

3月27日,君实生物宣布,由公司自主研发的抗PD-1单抗特瑞普利单抗(商品名:拓益,产品代号:JS001)联合阿昔替尼治疗黏膜黑色素瘤于近日获得美国食品药品监督管理局(FDA)孤儿药资格认定。

病例:特瑞普利单抗治疗肢端型恶性黑色素瘤患者持续获益

众所周知,黑色素瘤在世界范围不属于常见的恶性肿瘤,但近年来其发病率正逐步上升。不同于西方人群,我国黑色素瘤患者在发病机制、生物学行为、组织学形态、治疗方法及预后等方面均有所不同。既往针对西方人群的相关研究多针对皮肤黑色素瘤,而针对我国高发的肢端、黏膜等亚型黑色素瘤的相关研究较少。国产PD-1单抗对于我国黑色素瘤的疗效如何?这是医患皆关注的问题。本文分享1例CKIT和BRAF基因双突变的晚期肢端黑色

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ASCO 2020 来了:前列腺癌领域重磅研究盘点

2020年美国临床肿瘤学会(ASCO)年会终于跟随着时代的潮流“上线”了。今年虽然没有了线下集会的盛景,但层出不穷的各类研究依然热闹非凡。

ASCO 2020:K药联合仑伐替尼的“可乐组合”在肾透明细胞癌再显威

在II期临床研究Keynote-146中,入组了104名转移性透明细胞肾细胞癌患者接受帕博利珠单抗(K药)联合仑伐替尼治疗,也称为可乐组合。这些患者先前已经接受过2到3种疗法,如PD-1/L1疗法、P

ASCO 2020:三阴性乳腺癌节拍化疗探索(SYSUCC-001研究)

中山大学肿瘤防治中心的袁中玉教授和王曦教授领衔的SYSUCC-001研究是第一个采取节拍化疗模式的研究,今年更是入选了ASCO口头报告。

2020 ASCO前瞻:中美乳腺癌专家面对面专场直播预告

2020 ASCO Peer to Peer系列网络直播,中美乳腺癌专家前瞻解读ASCO报告,对话【乳腺癌治疗的现状与未来】,专场直播将于北京时间5月24日10:00开始。

ASCO 2020:大会摘要上线

ASCO 2020:大会摘要