J Biomed Mater Res A:钛或氧化锆植体颈部表面上皮封闭的效果

2019-02-13 MedSci MedSci原创

种植治疗的目标不仅要恢复咀嚼功能,还涉及美学的恢复。目前,氧化锆被广泛用作种植体基台的美学材料。因此,理解氧化锆作为植入材料的上皮密封的功效是非常重要的。我们比较了钛(Ti)或氧化锆(Zr)植入物颈部周围上皮(PIE)的封闭效果,以用于临床工作。拔除大鼠中上颌第一磨牙,并植入Ti或Zr种植体。通过免疫组织化学观察和HRP分析评估植体颈部PIE的封闭效果。此外,研究人员还评估了在Ti或Zr圆片上培养

种植治疗的目标不仅要恢复咀嚼功能,还涉及美学的恢复。目前,氧化锆被广泛用作种植体基台的美学材料。因此,理解氧化锆作为植入材料的上皮密封的功效是非常重要的。我们比较了钛(Ti)或氧化锆(Zr)植入物颈部周围上皮(PIE)的封闭效果,以用于临床工作。

拔除大鼠中上颌第一磨牙,并植入Ti或Zr种植体。通过免疫组织化学观察和HRP分析评估植体颈部PIE的封闭效果。此外,研究人员还评估了在Ti或Zr圆片上培养的大鼠口腔上皮细胞(OEC)的形态和功能变化。

结果显示,4周后,Ti和Zr植体颈部PIE显示出类似的结构。Zr植体似乎在组织-植入物界面处形成较弱的上皮封闭,并且在电子显微镜观察下显示出比Ti植体明显更少的粘附结构。在体外实验中,与在Ti平板上培养的OEC相比,在Zr平板上培养的OEC中观察到较低水平的粘附蛋白的表达水平。此外,Zr板上的细胞粘附性降低,而Ti板上的细胞迁移率低。

综上所述,该研究结果表明,Zr是美学植体材料的更好选择,但需要进一步改进与牙科植体颈部周围上皮伤口愈合过程的整合。

原始出处:

Atsuta I, Ayukawa Y, et al., Epithelial sealing effectiveness against titanium or zirconia implants surface. J Biomed Mater Res A. 2019 Feb 6. doi: 10.1002/jbm.a.36651.

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    2019-03-15 30397613
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    2019-04-21 sunylz
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    2019-02-13 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0