SCI REP:趋化素和网膜素-1与心衰风险的相关性分析!

2017-10-26 xing.T MedSci原创

该研究对于趋化素与心衰风险之间存在强烈的正相关提供了第一手的证据。脂肪因子网膜素-1和心衰风险之间的关联可能根据是否患有冠心病而有所不同。

脂肪因子趋化素和网膜素-1已被证实会影响心血管功能。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员旨在探讨趋化素和网膜素-1浓度分别与心力衰竭发生风险之间的纵向关联。

研究人员对嵌套在欧洲前瞻性调查癌症和营养(EPIC)-波茨坦队列(N = 27548)进行了一项病例队列研究,该队列包括一个随机抽取的样本和 在平均8.2±1.5年的随访期间发生的所有心衰病例。该研究共纳入212例心衰病例和2168例无心衰病例。

对已知的心血管危险因素进行多变量调整后,研究人员发现趋化素与心衰发生风险强烈相关(风险比为4.91;95%可信区间为2.57-9.39;P<0.0001)。在总体研究人群中,网膜素-1与心衰风险并无显著的相关性。然而,网膜素-1与心衰风险之间的关联是被有无患冠心病(CHD)而改变,表现为在没有CHD的患者中这种相关性的形状为线性(风险比为2.11;95%可信区间为1.36-3.27;线性P=0.0009),在既往有CHD的患者中,这种相关性的形状为U型(非线性P=0.006)。

该研究对于趋化素与心衰风险之间存在强烈的正相关提供了第一手的证据。脂肪因子网膜素-1和心衰风险之间的关联可能根据是否患有冠心病而有所不同。

原始出处:


Juliane Menzel,et al. Association between chemerin, omentin-1 and risk of heart failure in the population-based EPIC-Potsdam study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-14518-2

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    2017-10-26 胖红

    学习了很多东西

    0

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    2017-10-26 半夏微凉

    学习了谢谢分享

    0

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