Brit J Cancer:吸烟、饮酒与肝细胞癌以及肝内胆管癌风险之间的关系!

2018-03-12 xing.T MedSci原创

由此可见,这些发现表明在这个相对健康的人群中,戒烟和适度饮酒可以降低患HCC的风险。

虽然吸烟和饮酒是肝细胞癌(HCC)已知的危险因素,但尚不清楚它们是否也会增加肝内胆管癌(ICC)的风险。近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员分析了吸烟和饮酒与原发性肝癌之间的相关性。

肝癌合并项目是一个基于14个美国财团的前瞻性队列研究,该研究包含了1518741名受试者的数据(HCC患者n=1423 ,ICC 患者n=410)。研究人员采用比例风险回归估计了多变量调整后的风险比(HR)和95%可信区间(95%CI)。

在基线时的当前吸烟者发生HCC(HR=1.86,95%CI:1.57-2.20)和ICC(HR=1.47,95%CI为1.07-2.02)的风险增加。在戒烟>30年的受试者中,HCC的风险几乎相当于不吸烟者(HR=1.09,95%CI为0.74-1.61)。与不饮酒者相比,酗酒导致HCC风险增加87%(≥7杯/天的HR=1.87,95%CI为1.41-2.47)以及ICC的风险增加68%(≥5杯/天的HR=1.68,95%CI为0.99-2.86)。然而,<3杯/天的适量饮酒似乎与HCC风险呈负相关(0-0.5杯/天的HR=0.77,95%CI为0.67-0.89;0.5-1杯/天的HR=0.57,95%CI为0.44-0.73;1-3杯/天的HR=0.71,95%CI为0.58-0.87),但与ICC无关。

由此可见,这些发现表明在这个相对健康的人群中,戒烟和适度饮酒可以降低患HCC的风险。

原始出处:

Jessica L. Petrick, et al. Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0007-z

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    2018-11-04 sjq027
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    2018-07-12 想我

    很值得学习.进步了

    0

  4. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Apr 01 07:12:34 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298896, encodeId=f499298896e0, content=饮酒.抽烟的特别注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Fri Mar 23 07:55:54 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296264, encodeId=186a29626433, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Mar 14 23:03:29 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296021, encodeId=da5d1296021cc, content=<a href='/topic/show?id=ef11811e363' target=_blank style='color:#2F92EE;'>#肝内胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81173, encryptionId=ef11811e363, topicName=肝内胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Wed Mar 14 12:11:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628317, encodeId=acd0162831e0d, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Mar 14 12:11:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-07-31 xjy02
  5. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Apr 01 07:12:34 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298896, encodeId=f499298896e0, content=饮酒.抽烟的特别注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Fri Mar 23 07:55:54 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296264, encodeId=186a29626433, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Mar 14 23:03:29 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296021, encodeId=da5d1296021cc, content=<a href='/topic/show?id=ef11811e363' target=_blank style='color:#2F92EE;'>#肝内胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81173, encryptionId=ef11811e363, topicName=肝内胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Wed Mar 14 12:11:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628317, encodeId=acd0162831e0d, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Mar 14 12:11:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-05-08 jyzxjiangqin

    吸烟饮酒与肝细胞癌.

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2061721, encodeId=ba882061e2167, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sun Nov 04 00:11:00 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978654, encodeId=a5d719e865477, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Apr 01 07:12:34 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298896, encodeId=f499298896e0, content=饮酒.抽烟的特别注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Fri Mar 23 07:55:54 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296264, encodeId=186a29626433, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Mar 14 12:11:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-04-01 jyzxjiangqin

    吸烟饮酒与肝细胞之间关系.

    0

  7. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Apr 01 07:12:34 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298896, encodeId=f499298896e0, content=饮酒.抽烟的特别注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Fri Mar 23 07:55:54 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296264, encodeId=186a29626433, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Mar 14 12:11:00 CST 2018, time=2018-03-14, status=1, ipAttribution=)]
    2018-03-23 lhl629

    饮酒.抽烟的特别注意了

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Apr 01 07:12:34 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298896, encodeId=f499298896e0, content=饮酒.抽烟的特别注意了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ceb079804, createdName=lhl629, createdTime=Fri Mar 23 07:55:54 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296264, encodeId=186a29626433, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-03-14 天地飞扬

    了解一下.谢谢分享!

    0

  9. 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