Hypertension:骨骼肌脂肪含量与高血压发生有关!

2017-03-07 xing.T MedSci原创

该研究结果显示,在非洲血统的男性中降低的肌肉衰减与新发高血压之间存在相关性,并且独立于一般和中心性肥胖以及胰岛素抵抗。需要进一步研究以调整炎症、内脏和其他异位脂肪组织累积,并在其他人群样本中来确认这些研究结果。

骨骼肌异位脂肪组织浸润与胰岛素抵抗和糖尿病相关。近日,心血管权威杂志Hypertension上发表一篇研究文章,研究人员旨在评估以往研究的非洲裔美国男性人群中骨骼肌脂肪含量变化是否可以预测后续高血压的发生发展。

在多巴哥健康研究中,研究人员在非洲血统的男性中进行了一项前瞻性纵向研究(年龄范围为40-91岁),研究人员采用CT对参与者的小腿肌间脂肪组织、骨骼肌衰减进行了测量。高血压定义为收缩压≥140毫米汞柱,或舒张压≥90毫米汞柱,或接受抗高血压药物治疗。研究人员采用Logistic回归进行分析,调整了年龄、胰岛素抵抗、基线体重指数和体重指数6年期间变化值、基线腰围和腰围66年期间变化值以及其他潜在的混杂因素。

研究人员发现在研究之初746例的正常人中,在平均6.2年的随访中有321人(43%)发展成为高血压患者。在调整基线体重指数和体重指数6年期间变化值之后,研究人员发现降低的骨骼肌衰减(每SD对应的比值比和95%可信区间为1.3 [1.0-1.6])或基线腰围和腰围66年期间变化值(每SD对应的比值比和95%可信区间为1.3 [1.0-1.6])与新发高血压之间存在相关性。研究人员在增加的肌间脂肪与高血压之间没有观察到相关性。

该研究结果显示,在非洲血统的男性中降低的肌肉衰减与新发高血压之间存在相关性,并且独立于一般和中心性肥胖以及胰岛素抵抗。需要进一步研究以调整炎症、内脏和其他异位脂肪组织累积,并在其他人群样本中来确认这些研究结果。

原始出处:

Qian Zhao, et al. Muscle Attenuation Is Associated With Newly Developed Hypertension in Men of African Ancestry. Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08415

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    2017-09-26 feather89
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    2017-03-10 jiuling

    学习了谢谢分享

    0

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