精油抗菌水凝胶可促进烧伤创面愈合!

2022-01-22 MedSci原创 MedSci原创

多年来,人们已经开发出基于多糖的水凝胶来治疗烧伤。从芳香植物中提取的精油通常表现出优异的生物活性,尤其是抗菌性能。研究表明,与精油混合的抗菌水凝胶具有很大的烧伤愈合潜力。

多年来,人们已经开发出基于多糖的水凝胶来治疗烧伤。从芳香植物中提取的精油通常表现出优异的生物活性,尤其是抗菌性能。研究表明,与精油混合的抗菌水凝胶具有很大的烧伤愈合潜力。

该研究旨在开发一种含有精油的抗菌多糖水凝胶,用于修复烧伤皮肤。

图1 文章来源

桉树精油 (EEO)、生姜精油 (GEO) 和孜然精油 (CEO) 用于制备由羧甲基壳聚糖 (CMC) 和卡波姆 940 (CBM) 物理交联的有效抗菌水凝胶。使用抗菌活性研究、傅里叶变换红外光谱、X 射线衍射、扫描电子显微镜、气相色谱-质谱、流变分析、粘度、溶胀、失水率和水蒸气透过率研究制备和表征复合水凝胶。此外,通过细胞毒性和细胞迁移测定在体内评估水凝胶的生物相容性,并使用小鼠烧伤诱导的伤口在体内测试水凝胶的烧伤愈合能力。

结果显示,不同的精油与水凝胶基质(CMC 和 CBM)表现出不同的混合能力,这导致精油水凝胶粘度、溶胀和水蒸气传输的不同程度的降低。

在已开发的水凝胶中,CBM/CMC/EEO 水凝胶对金黄色葡萄球菌和大肠杆菌的抗菌活性分别为 46.26 ± 2.22% 和 63.05 ± 0.99%,有助于提高细胞活力(> 92.37%)和迁移活性。

图2分别在第3、7、14 和 21 天用阳性药物、CBM/CMC/EEO 水凝胶和盐水进行体内动物实验。( a ) 具有代表性的视觉伤口外观(刻度以毫米为单位表示尺寸)。( b ) 治疗的伤口愈合率比较

此外,如使用苏木精-伊红和马森三色染色法所观察到的结果所示,CBM/CMC/EEO 水凝胶通过促进真皮和表皮的恢复来加速小鼠烧伤模型中的伤口愈合。

酶联免疫吸附试验结果表明,CBM/CMC/EEO 水凝胶可通过 IL-6 和肿瘤坏死因子-α 下调和转化生长因子-β、血管内皮生长因子 (VEGF) 和表皮生长因子上调修复创面。

图3 采用ELISA法定量分析伤口组织中各种细胞因子的含量

本研究成功制备了一种多孔CBM/CMC/EEO水凝胶,该水凝胶具有高抗菌活性、良好的溶胀性、最佳的流变性能、优异的保水性和水蒸汽传输性能,对体外和体内皮肤修复效果显着。

此外,对 L929 细胞迁移的评估表明,CBM/CMC/EEO 水凝胶在 48 小时内促进了有效的细胞恢复。CBM/CMC/EEO 水凝胶显着改善了小鼠模型中的烧伤伤口愈合。伤口组织面积测量、组织学染色和 IL-6、TNF-α、TGF-β、VEGF 和 EGF 水平分析共同表明,CBM/CMC/EEO 水凝胶治疗显着加速了小鼠模型中的烧伤伤口修复。

结果表明,CBM/CMC/EEO水凝胶具有用作皮肤烧伤修复的有前途的烧伤敷料材料的潜力。

 

原始文章:

Huanhuan Wang, Yang Liu, Kun Cai, Bin Zhang, Shijie Tang, Wancong Zhang, Wenhua Liu, Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing, Burns & Trauma, Volume 9, 2021, tkab041

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    2022-12-21 qindq
  2. 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    2022-01-29 ms9000001995137444

    谢谢分享,值得学习#心力衰竭#

    0

  3. 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    2022-01-23 查查佳佳

    AASIS是由一个团队开发的专业工具,其目标是

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1632003, encodeId=d8291632003a6, content=<a href='/topic/show?id=b88a321e6b2' target=_blank style='color:#2F92EE;'>#创面#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32176, encryptionId=b88a321e6b2, topicName=创面)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fda21837820, createdName=qindq, createdTime=Wed Dec 21 00:46:13 CST 2022, time=2022-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1189034, encodeId=9c2a1189034d7, content=谢谢分享,值得学习<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3fa6482137, createdName=ms9000001995137444, createdTime=Sat Jan 29 09:39:11 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187361, encodeId=b584118e361d8, content=AASIS是由一个团队开发的专业工具,其目标是, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Jan 23 07:41:42 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187345, encodeId=6515118e3456f, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sun Jan 23 06:47:16 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308087, encodeId=1841130808eb4, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330904, encodeId=584a1330904c9, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461092, encodeId=e5061461092d6, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536094, encodeId=6498153609418, content=<a href='/topic/show?id=fe056e145d5' target=_blank style='color:#2F92EE;'>#烧伤创面#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67145, encryptionId=fe056e145d5, topicName=烧伤创面)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=175712654293, createdName=karmond, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584590, encodeId=c2a5158459097, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=)]
    2022-01-23 学医无涯

    学习一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1632003, encodeId=d8291632003a6, content=<a href='/topic/show?id=b88a321e6b2' target=_blank style='color:#2F92EE;'>#创面#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32176, encryptionId=b88a321e6b2, topicName=创面)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fda21837820, createdName=qindq, createdTime=Wed Dec 21 00:46:13 CST 2022, time=2022-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1189034, encodeId=9c2a1189034d7, content=谢谢分享,值得学习<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3fa6482137, createdName=ms9000001995137444, createdTime=Sat Jan 29 09:39:11 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187361, encodeId=b584118e361d8, content=AASIS是由一个团队开发的专业工具,其目标是, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Jan 23 07:41:42 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187345, encodeId=6515118e3456f, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sun Jan 23 06:47:16 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308087, encodeId=1841130808eb4, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330904, encodeId=584a1330904c9, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461092, encodeId=e5061461092d6, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536094, encodeId=6498153609418, content=<a href='/topic/show?id=fe056e145d5' target=_blank style='color:#2F92EE;'>#烧伤创面#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67145, encryptionId=fe056e145d5, topicName=烧伤创面)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=175712654293, createdName=karmond, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584590, encodeId=c2a5158459097, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=)]
    2022-01-14 tastas
  6. 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1632003, encodeId=d8291632003a6, content=<a href='/topic/show?id=b88a321e6b2' target=_blank style='color:#2F92EE;'>#创面#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32176, encryptionId=b88a321e6b2, topicName=创面)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fda21837820, createdName=qindq, createdTime=Wed Dec 21 00:46:13 CST 2022, time=2022-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1189034, encodeId=9c2a1189034d7, content=谢谢分享,值得学习<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3fa6482137, createdName=ms9000001995137444, createdTime=Sat Jan 29 09:39:11 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187361, encodeId=b584118e361d8, content=AASIS是由一个团队开发的专业工具,其目标是, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sun Jan 23 07:41:42 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1187345, encodeId=6515118e3456f, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Sun Jan 23 06:47:16 CST 2022, time=2022-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308087, encodeId=1841130808eb4, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330904, encodeId=584a1330904c9, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461092, encodeId=e5061461092d6, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536094, encodeId=6498153609418, content=<a href='/topic/show?id=fe056e145d5' target=_blank style='color:#2F92EE;'>#烧伤创面#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67145, encryptionId=fe056e145d5, topicName=烧伤创面)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=175712654293, createdName=karmond, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584590, encodeId=c2a5158459097, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri Jan 14 02:46:13 CST 2022, time=2022-01-14, status=1, ipAttribution=)]
    2022-01-14 lishizhe
  8. 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