Obstet Gynecol:常规宫颈长度筛查与产前皮质类固醇使用时机相关性分析!

2017-05-30 xing.T MedSci原创

与宫颈管长度不短的女性相比,通过常规经阴道超声筛查确定的宫颈较短患者,在开始使用促胎儿肺成熟的皮质类固醇激素后7天后发生分娩的风险更大。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员旨在评估妊娠中期常规经阴道短宫颈长度筛查与产前皮质类固醇使用时机之间的相关性。

研究员选用在2012年10月至2015年8月期间进行经阴道宫颈长度筛查程序后,对正常单胎妊娠和妊娠24至34周的自发早产患者进行了回顾性队列研究。该研究的主要结局为产前皮质类固醇给药到分娩的间隔不超过7天。次要结局为在初次类固醇注射后24小时至7天发生的分娩、类固醇给药到分娩的间隔、新生儿存活、新生儿重症监护病房住院时间和呼吸窘迫综合征。对潜在混杂因素进行调整后,研究人员使用多变量logistic 回归来估计产前类固醇激素给药时机与短宫颈诊断之间的相关性。

在266例符合条件的患者中,研究人员确定了69例妇女宫颈长度较短,197例妇女宫颈长度正常。两组间基线特征差异无统计学意义。在研究期间,69例子宫颈较短的妇女中有64例(92.8%)和197例宫颈长度正常妇女中有176例(89.3%)在分娩前至少接受一次类固醇注射(P=0.411)。69例子宫颈较短的妇女中有33例(47.8%)相比于197例宫颈长度正常妇女中有126例(64%)在分娩前7天内给予了类固醇(P=0.015;调整后的比值比为0.51,95%CI为0.29-0.9)。在诊断为子宫颈较短的患者中,从类固醇给药到分娩间隔中位数为8天,而宫颈正常的患者为3天(P <0.001)。

与宫颈管长度不短的女性相比,通过常规经阴道超声筛查确定的宫颈较短患者,在开始使用促胎儿肺成熟的皮质类固醇激素后7天后发生分娩的风险更大。

原始出处:

Sahasrabudhe, et al. Universal Cervical Length Screening and Antenatal Corticosteroid Timing.Obstetrics & Gynecology.2017. http://journals.lww.com/greenjournal/Fulltext/2017/06000/Universal_Cervical_Length_Screening_and_Antenatal.21.aspx

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    2018-04-01 yhy100200
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channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Thu Jun 01 14:42:00 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043967, encodeId=49fe204396eec, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Jan 29 23:42:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204661, encodeId=1ee920466151, content=学习了,谢谢分享, 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    2017-06-01 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1837249, encodeId=e409183e24903, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Jul 17 05:42:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011304, encodeId=b25d20113044c, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, 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    2017-06-01 qilu_qi
  6. 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  7. 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  8. 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    2017-05-31 龙胆草

    学习了,谢谢分享

    0

  9. 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    2017-05-31 半夏微凉

    阅读了谢谢分享

    0

  10. 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    2017-05-31 忠诚向上

    好好努力学习

    0