Sci Rep:一种特殊的花青素,或为癌症治疗带来希望

2018-04-10 佚名 中国生物技术网

众所周知,浆果含有大量的维生素和对健康有益的营养物质。最近,研究人员们又发现了一个新的益处。

众所周知,浆果含有大量的维生素和对健康有益的营养物质。最近,研究人员们又发现了一个新的益处。

果的天然颜色来自于被称为花青素的色素,属于黄酮类化合物。花青素是一种水溶性的色素,根据pH值不同,它会呈现红、紫或蓝色。它不仅存在于浆果中,它们也大量存在于血橙、黑米和黑豆中。

虽然过去不乏此类研究,但在最近,研究人员发现一种特殊的花青素似乎能为癌症治疗带来希望。这项研究近日发表在《Scientific Reports》上。

东芬兰大学药剂学博士Minna Rahnasto-Rilla是这篇研究论文的第一作者,他说:“这项研究得到的最终结果与矢车菊素有关,这是一种大量存在于野生覆盆子、黑醋栗和越橘中的花青素。”

在讨论矢车菊素的这些特征之前,我们需要介绍另一种起作用的物质:sirtuins。它是一类调节重要生物途径的蛋白质。衰老会导致sirtuins功能发生变化,这些变化会导致多种严重的疾病。比如Sirtuin6(简称SIRT6)负责调节葡萄糖代谢并确保DNA修复以及维持端粒长度。

而矢车菊素这种存在于浆果中的色素能够增加人结直肠癌细胞中SIRT6酶的水平,并提升肿瘤抑制基因的表达。研究人员认为,矢车菊素最终能够被用于某些癌症的治疗途径。

他们还设计了一个基于计算机的模型,该模型能够预测植物中不同类黄酮化合物如何调节SIRT6酶,并取得了良好的结果。该研究还为开发调节SIRT6功能的新药物铺平了道路。

但是该结果并不意味着“浆果治愈癌症”或者“浆果能治疗癌症”。再次强调,浆果营养丰富,并且是很多健康饮食的成分。然而,这并不代表它能够治愈癌症。该研究只表明,浆果中的一种特定化合物可以被用于对抗包括癌症在内的某些疾病。

原始出处:

Minna Rahnasto-Rilla,et al.Natural polyphenols as sirtuin 6 modulators.Sci Rep.8, Article number: 4163 (2018).

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    2018-04-13 大爰

    学习了谢谢分享!!

    0

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    2018-04-12 drj2005
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    2018-04-11 jihuaijun1112

    学习学习学习

    0