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Sci Rep: 乙酰胆碱酯酶抑制剂可降低痴呆患者缺血性卒中发生的风险

2016-07-15 MedSci MedSci原创

乙酰胆碱酯酶抑制剂痴呆缺血性卒中
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老年痴呆症患者的卒中发生风险增加。乙酰胆碱酯酶抑制剂（AChEIs）有保护血管内皮功能的作用和抗炎的特性。研究者调查无卒中史的应用AChEIs药物的痴呆患者，缺血性脑卒中的风险。使用1999到2008年台湾国家健康保险数据库中的数据，共有50岁以上的无卒中史的老年痴呆症患者37352例符合条件。竞争风险校正后，采用倾向评分匹配的Cox比例风险模型分析结果。与相匹配的倾向得分相比（240.8/100

老年痴呆症患者的卒中发生风险增加。乙酰胆碱酯酶抑制剂（AChEIs）有保护血管内皮功能的作用和抗炎的特性。研究者调查无卒中史的应用AChEIs药物的痴呆患者，缺血性脑卒中的风险。

使用1999到2008年台湾国家健康保险数据库中的数据，共有50岁以上的无卒中史的老年痴呆症患者37352例符合条件。竞争风险校正后，采用倾向评分匹配的Cox比例风险模型分析结果。与相匹配的倾向得分相比（240.8/10000人年），应用AChEIs患者缺血性脑卒中的发病率较低（160.3/10000人年）。根据倾向评分匹配的Cox比例风险模型，缺血性卒中发生的校正危险比为0.508（95%CI，0.434-0.594；）。AChEIs使用者和非使用者之间的全因死亡率的差异无统计学意义。

总之，无卒中史的老年痴呆症患者，AChEIs治疗与降低缺血性卒中风险相关，但不增加生存率。

原始出处：

Lin YT3, Wu PH，et al. Association between acetylcholinesterase inhibitors and risk of stroke in patients with dementia. Sci Rep. 2016 Jul 5.

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    2017-02-10 yuanming7

    #乙酰胆碱酯酶#

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    2017-05-29 crystal0562

    #痴呆患者#

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    2016-12-15 doctorzheng

    #乙酰胆碱#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1797694, encodeId=680d1e9769442, content=<a href='/topic/show?id=ac22234e709' target=_blank style='color:#2F92EE;'>#乙酰胆碱酯酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23477, encryptionId=ac22234e709, topicName=乙酰胆碱酯酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Feb 10 04:24:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009075, encodeId=143c20090e541, content=<a href='/topic/show?id=3ed8e121172' target=_blank style='color:#2F92EE;'>#痴呆患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71211, encryptionId=3ed8e121172, topicName=痴呆患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Mon May 29 10:24:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085102, encodeId=e8712085102c3, content=<a href='/topic/show?id=3f91234e293' target=_blank style='color:#2F92EE;'>#乙酰胆碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23472, encryptionId=3f91234e293, topicName=乙酰胆碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Thu Dec 15 00:24:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892776, encodeId=9ee11892e76f6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Oct 19 16:24:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145559, encodeId=feab145559aa, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:35:34 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851332, encodeId=34d41851332f2, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Sep 30 06:24:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806097, encodeId=dab1180609e68, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Jan 14 17:24:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518624, encodeId=4f10151862480, content=<a href='/topic/show?id=e85583501c7' target=_blank style='color:#2F92EE;'>#胆碱酯酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83501, encryptionId=e85583501c7, topicName=胆碱酯酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dfb11165190, createdName=gj0735, createdTime=Sun Jul 17 10:24:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527385, encodeId=f17a152e38536, content=<a href='/topic/show?id=10b483495a2' target=_blank style='color:#2F92EE;'>#胆碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83495, encryptionId=10b483495a2, topicName=胆碱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce6211859522, createdName=grace5704, createdTime=Sun Jul 17 10:24:00 CST 2016, time=2016-07-17, status=1, ipAttribution=)]
    2016-10-19 guihongzh

    #缺血性#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1797694, encodeId=680d1e9769442, content=<a href='/topic/show?id=ac22234e709' target=_blank style='color:#2F92EE;'>#乙酰胆碱酯酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23477, encryptionId=ac22234e709, topicName=乙酰胆碱酯酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Feb 10 04:24:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009075, encodeId=143c20090e541, content=<a href='/topic/show?id=3ed8e121172' target=_blank style='color:#2F92EE;'>#痴呆患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71211, encryptionId=3ed8e121172, topicName=痴呆患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Mon May 29 10:24:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085102, encodeId=e8712085102c3, content=<a href='/topic/show?id=3f91234e293' target=_blank style='color:#2F92EE;'>#乙酰胆碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23472, encryptionId=3f91234e293, topicName=乙酰胆碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Thu Dec 15 00:24:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892776, encodeId=9ee11892e76f6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Oct 19 16:24:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145559, encodeId=feab145559aa, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:35:34 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851332, encodeId=34d41851332f2, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Sep 30 06:24:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806097, encodeId=dab1180609e68, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Jan 14 17:24:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518624, encodeId=4f10151862480, content=<a href='/topic/show?id=e85583501c7' target=_blank style='color:#2F92EE;'>#胆碱酯酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83501, encryptionId=e85583501c7, topicName=胆碱酯酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dfb11165190, createdName=gj0735, createdTime=Sun Jul 17 10:24:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527385, encodeId=f17a152e38536, content=<a href='/topic/show?id=10b483495a2' target=_blank style='color:#2F92EE;'>#胆碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83495, encryptionId=10b483495a2, topicName=胆碱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce6211859522, createdName=grace5704, createdTime=Sun Jul 17 10:24:00 CST 2016, time=2016-07-17, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    学习了，好文值得点赞！

    0

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    2016-09-30 jklm09

    #抑制剂#

    0

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    2017-01-14 12498da4m32(暂无昵称)

    #缺血性卒#

    0

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    2016-07-17 gj0735

    #胆碱酯酶#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1797694, encodeId=680d1e9769442, content=<a href='/topic/show?id=ac22234e709' target=_blank style='color:#2F92EE;'>#乙酰胆碱酯酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23477, encryptionId=ac22234e709, topicName=乙酰胆碱酯酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Feb 10 04:24:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009075, encodeId=143c20090e541, content=<a href='/topic/show?id=3ed8e121172' target=_blank style='color:#2F92EE;'>#痴呆患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71211, encryptionId=3ed8e121172, topicName=痴呆患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Mon May 29 10:24:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085102, encodeId=e8712085102c3, content=<a href='/topic/show?id=3f91234e293' target=_blank style='color:#2F92EE;'>#乙酰胆碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23472, encryptionId=3f91234e293, topicName=乙酰胆碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Thu Dec 15 00:24:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892776, encodeId=9ee11892e76f6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Oct 19 16:24:00 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145559, encodeId=feab145559aa, content=学习了，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:35:34 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851332, encodeId=34d41851332f2, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Sep 30 06:24:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806097, encodeId=dab1180609e68, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sat Jan 14 17:24:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518624, encodeId=4f10151862480, content=<a href='/topic/show?id=e85583501c7' target=_blank style='color:#2F92EE;'>#胆碱酯酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83501, encryptionId=e85583501c7, topicName=胆碱酯酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8dfb11165190, createdName=gj0735, createdTime=Sun Jul 17 10:24:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527385, encodeId=f17a152e38536, content=<a href='/topic/show?id=10b483495a2' target=_blank style='color:#2F92EE;'>#胆碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83495, encryptionId=10b483495a2, topicName=胆碱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce6211859522, createdName=grace5704, createdTime=Sun Jul 17 10:24:00 CST 2016, time=2016-07-17, status=1, ipAttribution=)]
    2016-07-17 grace5704

    #胆碱#

    0