Heart:冠状动脉搭桥术后睡眠呼吸暂停与心血管结局

2020-05-21 MedSci原创 MedSci原创

CABG患者睡眠呼吸暂停与MACCE发生增加独立相关。

冠状动脉疾病晚期患者将接受冠状动脉旁路移植术(CABG),睡眠呼吸暂停是否是其危险标志尚不清楚。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在评估接受非急诊CABG患者睡眠呼吸暂停与主要不良心脏和脑血管事件(MACCE)之间的关联。

这是一项于2013年11月至2018年12月期间进行的前瞻性队列研究。研究人员招募了来自四家公立医院的非急诊CABG患者,在CABG前使用腕戴式Watch-PAT 200设备进行过夜睡眠检查。

在完成研究的1007名患者中,有513名(50.9%)患者被诊断出睡眠呼吸暂停(定义为每小时呼吸暂停-呼吸不足指数≥15次事件)。在平均2.1年的随访期内,有124例患者发生了MACCE(2年累积发生率估计为11.3%)。共有33例(2.5%)心脏病死亡患者,42例(3.7%)非致命性心肌梗塞患者,50例(4.9%)非致命性卒中和36例(3.2%)计划外血运重建患者。睡眠呼吸暂停组MACCE的发生率高于非睡眠呼吸暂停组(2年评估分别为14.7% vs. 7.8%;p=0.002)。睡眠呼吸暂停可在未经校正的Cox回归分析(HR为1.69;95%CI为1.18至2.43)中预测MACCE的发生率,并在校正了年龄、性别、体重指数、左心室射血分数、糖尿病、高血压、慢性肾脏疾病和白天过度嗜睡后仍具有统计学意义(校正后HR为1.57; 95%CI为1.09至2.25)。

由此可见,CABG患者睡眠呼吸暂停与MACCE发生增加独立相关。

原始出处:

Chieh Yang Koo.et al.Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting.heart.2020.https://heart.bmj.com/content/early/2020/05/18/heartjnl-2019-316118

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    2020-05-23 zhaojie88
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    2020-05-23 zzc2214
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