Diabetic Med:德国成年人的血糖状况和抑郁症状关系如何?

2018-12-25 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于德国成年人的血糖状况和抑郁症状的德国健康访谈和成人检查调查结果(DEGS1)的研究。在全国范围内德国成年人群样本中检查血糖状态与抑郁症状之间的关系。 研究人员对全国德国2008-2011成人健康访谈和检查调查(DEGS1)中的6385名18-79岁年龄段的参与者进行了横断面分析。血糖状态分类如下:诊断为糖尿病(自我报告诊断或接受

近日,国际杂志 《Diabetic Med》上在线发表一项关于德国成年人的血糖状况和抑郁症状的德国健康访谈和成人检查调查结果(DEGS1)的研究。在全国范围内德国成年人群样本中检查血糖状态与抑郁症状之间的关系。

研究人员对全国德国2008-2011成人健康访谈和检查调查(DEGS1)中的638518-79岁年龄段的参与者进行了横断面分析。血糖状态分类如下:诊断糖尿病(自我报告诊断或接受抗糖尿病药物治疗);未确诊的糖尿病HBA 1C48毫摩尔/摩尔[6.5]);前驱糖尿病(HbA 1c 39-47 mmol / mol [5.7-6.4]; 或正常血糖(HbA 1c<39mmol/mol [<5.7])。目前的抑郁症状使用患者健康问卷抑郁量表(PHQ-9)进行测量,并定义为抑郁症状加重(PHQ-9评分10;二分变量)和抑郁症状严重程度(PHQ-9评分,范围0-27)点;连续变量)。使用多变量逻辑(加重的抑郁症状)和线性(抑郁症状的严重性)回归模型分析血糖状态和HbA 1c与两种抑郁症状变量的关联。

校正社会人口统计学和健康行为的模型,与正常血糖相比,诊断为糖尿病但不是前驱糖尿病或未确诊的糖尿病,与抑郁症状加重(优势比1.55,95CI 1.00-2.41)和抑郁症状严重程度(β系数0.71,95CI 0.23-1.19)相关。诊断为糖尿病服用药物和未服用抗糖尿病药物的人群之间的相关性相似。在未诊断为糖尿病的人群中,未发现HbA 1c与抑郁症状之间存在关联。

诊断为糖尿病,但不是前驱糖尿病,未确诊的糖尿病与德国成年人的抑郁症状有关。因此,有必要研究社会心理和生物学机制,以解释糖尿病诊断与抑郁症状之间的关系。

原始出处:

B. WeikertA. K. ButteryC. Heidemannet al. Glycaemic status and depressive symptoms among adults in Germany: results from the German Health Interview and Examination Survey for Adults (DEGS1)

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