Int J Antimicrob Ag:住院儿童的耐万古霉素肠球菌定植率较高 尤其是这个病房

2017-06-08 选题审校:梁舒瑶 编辑:贾朝娟 环球医学

2017年5月,发表在《Int J Antimicrob Agents》的一项统评价和荟萃分析调查了住院儿童患者中耐万古霉素肠球菌定植、风险因素和感染风险。

2017年5月,发表在《Int J Antimicrob Agents》的一项统评价和荟萃分析调查了住院儿童患者中耐万古霉素肠球菌定植、风险因素和感染风险。研究结果显示,住院儿童具有较高的VRE定植率。重要的是,定植儿童几乎有9倍的可能性出现后续VRE感染

本研究旨在估算住院儿童的耐万古霉素肠球菌(VRE)定植率和意义。系统检索PubMed和EMBASE数据库(截止日期为2016年5月29日),识别出评估非暴发期内住院儿童胃肠道VRE定植的研究。在945个无重复的引用中,19项研究的20234名儿童被纳入。总的和儿童重症监护室(PICU)的VRE定植率均为5%[总的95%置信区间(CI)3-8%,PICU 95%CI 2~9%],但血液/肿瘤病房是23%(95%CI 18~29%)。排除了在血液/肿瘤病房开展的研究,在单变量和多变量分析中报道的定植率明显高于其他研究(P=0.001)。先前万古霉素[风险比(RR)4.34,95% CI 2.77~6.82]或头孢他定(RR=4.15,95% CI 2.69~6.4)使用是VRE定植的一个风险因素。重要的是,VRE定植会增加后续VRE感染的风险(RR=8.75,95% CI 3.19~23.97)。

总体上,在开展目标筛选的机构中,住院儿童具有较高的VRE定植率。重要的是,定植儿童几乎有9倍的可能性出现后续VRE感染。高流行率机构应该考虑特殊抗生素的明智使用以及强化感染控制措施。同时,血液/肿瘤疾病儿童中高VRE定植率显示其为高风险人群。

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    2018-02-06 xjy02
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    2017-06-11 changjiu

    要重视这个问题

    0

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    2017-06-08 虈亣靌

    值得学习,临床需要注意

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2084228, encodeId=146b2084228fa, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Feb 06 00:24:00 CST 2018, time=2018-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857462, encodeId=c99e185e462f4, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Thu Mar 29 23:24:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209242, encodeId=382a209242bc, content=要重视这个问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jun 11 07:35:20 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491716, encodeId=0f661491e1691, content=<a href='/topic/show?id=130a8158305' target=_blank style='color:#2F92EE;'>#肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81583, encryptionId=130a8158305, topicName=肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3c98898784, createdName=psybestwish, createdTime=Sat Jun 10 06:24:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208240, encodeId=b8e9208240cc, content=值得学习,临床需要注意, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 08 18:23:58 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208230, encodeId=bb9020823074, content=学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhQkEvDREF6S2vZq3ZIpUYjdqicKVoAWaJSGoe8xNvS6o6QpmOlh2AQ7xuUpj8NiaDjJJgjbc7Xj3T6/0, createdBy=1c242047915, createdName=daiyaozu, createdTime=Thu Jun 08 17:38:04 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 daiyaozu

    学习了,不错

    0