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EUR J Cancer：治疗结直肠癌患者的III期RECOURSE临床试验的亚组中 trifluridine / tipiracil（TAS-102）与安慰剂

2017-12-26 MedSci MedSci原创

直肠癌患者trifluridinetipiracil
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EUR J Cancer<span lang="ZH-CN" style="font-family:DengXian;mso-ascii-font-family: Calibri;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:DengXian; mso-fareast-theme-font:minor-fareast;mso-

EUR J Cancer：治疗结直肠癌患者的III期RECOURSE临床试验的亚组中 trifluridine / tipiracil（TAS-102）与安慰剂的对比

在III期RECOURSE试验中，trifluridine / tipiracil（TAS-102）在可接受的毒性条件下，能够延长总生存期（OS）和无进展生存期（PFS）。来自比利时的研究人员分析调查了trifluridine / tipiracil在RECOURSE亚组中的有效性和安全性，对难治性或不能耐受标准治疗的转移性结直肠癌患者进行了系统分析。研究人员使用COX危险模式评估法评估了来自美国、欧洲和日本的转移性结直肠癌患者，通过KRAS状态来评估治疗的安全性和耐受性。

结果显示，在入组的768名患者中（美国，n=99；欧洲，n=403；日本，n=266），trifluridine / tipiracil组中位总生存期（OS）在这三个地区中为6.5-7.8月（美国：HR 0.56，95% CI 0.34-0.94，P=0.0277；欧洲：HR 0.62，95% CI 0.48-0.80，P=0.0002；日本：HR 0.75，95% CI 0.57-1.00，P=0.0470），而该数值在安慰剂组中为4.3-6.7月。同时无进展生存期（PFS）在trifluridine / tipiracil组中为2.0-2.8月，在安慰剂组中为1.7-1.8月。

因此我们可以得出，不论年龄，地域或KRAS状态，Trifluridine / tipiracil在所有亚组均有效。

 

原始出处：

Van Cutsem, Eric, et al. "The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer." European Journal of Cancer 2018 90: 63-72. doi.org/10.1016/j.ejca.

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    2018-08-28 ms8435843352634314

    #TAS-102#

    0

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    2018-02-22 juliusluan78

    #III#

    0

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    2018-07-20 sunyl07

    #course#

    0

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    2017-12-28 wleon8895

    #安慰剂#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1661530, encodeId=5fe4166153099, content=<a href='/topic/show?id=706f1e139a8' target=_blank style='color:#2F92EE;'>#TAS-102#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17139, encryptionId=706f1e139a8, topicName=TAS-102)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cb525318216, createdName=ms8435843352634314, createdTime=Tue Aug 28 10:19:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915984, encodeId=4af619159848a, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Thu Feb 22 10:19:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783664, encodeId=50021e83664ea, content=<a href='/topic/show?id=81b451265b' target=_blank style='color:#2F92EE;'>#course#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5126, encryptionId=81b451265b, topicName=course)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Fri Jul 20 20:19:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304348, encodeId=9a18130434872, content=<a href='/topic/show?id=81724580886' target=_blank style='color:#2F92EE;'>#安慰剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45808, encryptionId=81724580886, topicName=安慰剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453054, encodeId=287e145305495, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477857, encodeId=83bc14e785780, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594498, encodeId=2ad0159449822, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=)]
    2017-12-28 crystal0564

    #结直肠#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1661530, encodeId=5fe4166153099, content=<a href='/topic/show?id=706f1e139a8' target=_blank style='color:#2F92EE;'>#TAS-102#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17139, encryptionId=706f1e139a8, topicName=TAS-102)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cb525318216, createdName=ms8435843352634314, createdTime=Tue Aug 28 10:19:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915984, encodeId=4af619159848a, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Thu Feb 22 10:19:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783664, encodeId=50021e83664ea, content=<a href='/topic/show?id=81b451265b' target=_blank style='color:#2F92EE;'>#course#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5126, encryptionId=81b451265b, topicName=course)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Fri Jul 20 20:19:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304348, encodeId=9a18130434872, content=<a href='/topic/show?id=81724580886' target=_blank style='color:#2F92EE;'>#安慰剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45808, encryptionId=81724580886, topicName=安慰剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453054, encodeId=287e145305495, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477857, encodeId=83bc14e785780, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594498, encodeId=2ad0159449822, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=)]
    2017-12-28 ms3117646317107274

    #S-1#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1661530, encodeId=5fe4166153099, content=<a href='/topic/show?id=706f1e139a8' target=_blank style='color:#2F92EE;'>#TAS-102#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17139, encryptionId=706f1e139a8, topicName=TAS-102)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cb525318216, createdName=ms8435843352634314, createdTime=Tue Aug 28 10:19:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915984, encodeId=4af619159848a, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Thu Feb 22 10:19:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783664, encodeId=50021e83664ea, content=<a href='/topic/show?id=81b451265b' target=_blank style='color:#2F92EE;'>#course#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5126, encryptionId=81b451265b, topicName=course)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Fri Jul 20 20:19:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304348, encodeId=9a18130434872, content=<a href='/topic/show?id=81724580886' target=_blank style='color:#2F92EE;'>#安慰剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45808, encryptionId=81724580886, topicName=安慰剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cce318, createdName=wleon8895, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453054, encodeId=287e145305495, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477857, encodeId=83bc14e785780, content=<a href='/topic/show?id=944315e85c0' target=_blank style='color:#2F92EE;'>#S-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15785, encryptionId=944315e85c0, topicName=S-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6477383481, createdName=ms3117646317107274, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594498, encodeId=2ad0159449822, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Dec 28 09:19:00 CST 2017, time=2017-12-28, status=1, ipAttribution=)]
    2017-12-28 智智灵药

    #III期#

    0