J Cosmet Dermatol:多植物提取物产品可通过抗氧化和抗酪氨酸酶的产生来改善皮肤光老化

2022-08-16 MedSci原创 MedSci原创

除了化妆品的局部应用外,营养品代表了预防皮肤光老化和皮肤癌的一种有希望的策略。

除了化妆品的局部应用外,营养品代表了预防皮肤光老化和皮肤癌的一种有希望的策略。近日,发表于J Cosmet Dermatol的一项研究探究了一种含有甜瓜提取物、针叶樱桃提取物、橄榄果、芦荟凝胶、葡萄籽提取物和番茄红素的新型多植物提取物产品的效果。

研究人员进行了一项随机、安慰剂对照、双盲临床试验,并建立了紫外线(UV)诱导的小鼠光老化模型。纳入了55名45-60岁的健康受试者参加了试验,并随机选择口服该产品或安慰剂,为期12周。使用非侵入性技术测量皮肤老化和美白指数。使用90只7-8周的Balb/c小鼠随机分为六组:正常组、紫外线组、紫外线+载体组、紫外线+不同剂量的本品(分别为0.500g/kg.BW, 0.250g/kg.BW, 0.125g/kg.BW)。除正常组外,背中部地区用UVA+UVB照射8周。测定了氧化应激、酪氨酸酶和背中部皮肤的组织学分析等因素。

结果,在临床试验中,实验组的TEWL、水合作用、皮脂、弹性以及L*、a*、黑色素指数与基线的变化、ITA°都有明显改善。在动物实验中,与紫外线+载体组相比,紫外线+高剂量组的丙二醛(MDA)和酪氨酸酶明显降低,但超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)和谷胱甘肽过氧化物酶(GSH-Px)的水平却升高。紫外线+中等剂量组显示,MDA和GSH-Px明显改善,而紫外线+低剂量组仅显示GSH-Px的改善。组织学上的光老化表现在紫外线+高剂量组和中等剂量组中被削弱了。

综上所述,该研究结果表明,多植物提取物产品可能通过抗氧化和抗酪氨酸酶的方式改善皮肤光老化。

 

原始出处:

Yang Xie, et al., A new product of multi-plant extracts improved skin photoaging: An oral intake in vivo study. J Cosmet Dermatol. 2022 Aug;21(8):3406-3415. doi: 10.1111/jocd.14620.

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    2023-06-18 xuyong535
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    2022-10-27 tcm99hq
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    2023-05-16 一闲
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