J Cosmet Dermatol:多植物提取物产品可通过抗氧化和抗酪氨酸酶的产生来改善皮肤光老化

2022-08-16 MedSci原创 MedSci原创

除了化妆品的局部应用外,营养品代表了预防皮肤光老化和皮肤癌的一种有希望的策略。

除了化妆品的局部应用外,营养品代表了预防皮肤光老化和皮肤癌的一种有希望的策略。近日,发表于J Cosmet Dermatol的一项研究探究了一种含有甜瓜提取物、针叶樱桃提取物、橄榄果、芦荟凝胶、葡萄籽提取物和番茄红素的新型多植物提取物产品的效果。

研究人员进行了一项随机、安慰剂对照、双盲临床试验,并建立了紫外线(UV)诱导的小鼠光老化模型。纳入了55名45-60岁的健康受试者参加了试验,并随机选择口服该产品或安慰剂,为期12周。使用非侵入性技术测量皮肤老化和美白指数。使用90只7-8周的Balb/c小鼠随机分为六组:正常组、紫外线组、紫外线+载体组、紫外线+不同剂量的本品(分别为0.500g/kg.BW, 0.250g/kg.BW, 0.125g/kg.BW)。除正常组外,背中部地区用UVA+UVB照射8周。测定了氧化应激、酪氨酸酶和背中部皮肤的组织学分析等因素。

结果,在临床试验中,实验组的TEWL、水合作用、皮脂、弹性以及L*、a*、黑色素指数与基线的变化、ITA°都有明显改善。在动物实验中,与紫外线+载体组相比,紫外线+高剂量组的丙二醛(MDA)和酪氨酸酶明显降低,但超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)和谷胱甘肽过氧化物酶(GSH-Px)的水平却升高。紫外线+中等剂量组显示,MDA和GSH-Px明显改善,而紫外线+低剂量组仅显示GSH-Px的改善。组织学上的光老化表现在紫外线+高剂量组和中等剂量组中被削弱了。

综上所述,该研究结果表明,多植物提取物产品可能通过抗氧化和抗酪氨酸酶的方式改善皮肤光老化。

 

原始出处:

Yang Xie, et al., A new product of multi-plant extracts improved skin photoaging: An oral intake in vivo study. J Cosmet Dermatol. 2022 Aug;21(8):3406-3415. doi: 10.1111/jocd.14620.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2070275, encodeId=492420e027538, content=<a href='/topic/show?id=db9562e5542' target=_blank style='color:#2F92EE;'>#植物提取物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62755, encryptionId=db9562e5542, topicName=植物提取物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun May 28 21:05:02 CST 2023, time=2023-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745406, encodeId=5d041e454061e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Sun Jun 18 19:05:02 CST 2023, time=2023-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783644, encodeId=46ec1e836444d, content=<a href='/topic/show?id=f6c9511ec2' target=_blank style='color:#2F92EE;'>#CoSM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5117, encryptionId=f6c9511ec2, topicName=CoSM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Thu Oct 27 16:05:02 CST 2022, time=2022-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897054, encodeId=3a08189e054c7, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue May 16 11:05:02 CST 2023, time=2023-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388070, encodeId=c76213880e091, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Tue Aug 16 13:05:02 CST 2022, time=2022-08-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2070275, encodeId=492420e027538, content=<a href='/topic/show?id=db9562e5542' target=_blank style='color:#2F92EE;'>#植物提取物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62755, encryptionId=db9562e5542, topicName=植物提取物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun May 28 21:05:02 CST 2023, time=2023-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745406, encodeId=5d041e454061e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Sun Jun 18 19:05:02 CST 2023, time=2023-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783644, encodeId=46ec1e836444d, content=<a href='/topic/show?id=f6c9511ec2' target=_blank style='color:#2F92EE;'>#CoSM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5117, encryptionId=f6c9511ec2, topicName=CoSM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Thu Oct 27 16:05:02 CST 2022, time=2022-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897054, encodeId=3a08189e054c7, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue May 16 11:05:02 CST 2023, time=2023-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388070, encodeId=c76213880e091, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Tue Aug 16 13:05:02 CST 2022, time=2022-08-16, status=1, ipAttribution=)]
    2023-06-18 xuyong535
  3. [GetPortalCommentsPageByObjectIdResponse(id=2070275, encodeId=492420e027538, content=<a href='/topic/show?id=db9562e5542' target=_blank style='color:#2F92EE;'>#植物提取物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62755, encryptionId=db9562e5542, topicName=植物提取物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun May 28 21:05:02 CST 2023, time=2023-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745406, encodeId=5d041e454061e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Sun Jun 18 19:05:02 CST 2023, time=2023-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783644, encodeId=46ec1e836444d, content=<a href='/topic/show?id=f6c9511ec2' target=_blank style='color:#2F92EE;'>#CoSM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5117, encryptionId=f6c9511ec2, topicName=CoSM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Thu Oct 27 16:05:02 CST 2022, time=2022-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897054, encodeId=3a08189e054c7, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue May 16 11:05:02 CST 2023, time=2023-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388070, encodeId=c76213880e091, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Tue Aug 16 13:05:02 CST 2022, time=2022-08-16, status=1, ipAttribution=)]
    2022-10-27 tcm99hq
  4. [GetPortalCommentsPageByObjectIdResponse(id=2070275, encodeId=492420e027538, content=<a href='/topic/show?id=db9562e5542' target=_blank style='color:#2F92EE;'>#植物提取物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62755, encryptionId=db9562e5542, topicName=植物提取物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun May 28 21:05:02 CST 2023, time=2023-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745406, encodeId=5d041e454061e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Sun Jun 18 19:05:02 CST 2023, time=2023-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783644, encodeId=46ec1e836444d, content=<a href='/topic/show?id=f6c9511ec2' target=_blank style='color:#2F92EE;'>#CoSM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5117, encryptionId=f6c9511ec2, topicName=CoSM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Thu Oct 27 16:05:02 CST 2022, time=2022-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897054, encodeId=3a08189e054c7, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue May 16 11:05:02 CST 2023, time=2023-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388070, encodeId=c76213880e091, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Tue Aug 16 13:05:02 CST 2022, time=2022-08-16, status=1, ipAttribution=)]
    2023-05-16 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=2070275, encodeId=492420e027538, content=<a href='/topic/show?id=db9562e5542' target=_blank style='color:#2F92EE;'>#植物提取物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62755, encryptionId=db9562e5542, topicName=植物提取物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sun May 28 21:05:02 CST 2023, time=2023-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745406, encodeId=5d041e454061e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Sun Jun 18 19:05:02 CST 2023, time=2023-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783644, encodeId=46ec1e836444d, content=<a href='/topic/show?id=f6c9511ec2' target=_blank style='color:#2F92EE;'>#CoSM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5117, encryptionId=f6c9511ec2, topicName=CoSM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Thu Oct 27 16:05:02 CST 2022, time=2022-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1897054, encodeId=3a08189e054c7, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue May 16 11:05:02 CST 2023, time=2023-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388070, encodeId=c76213880e091, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Tue Aug 16 13:05:02 CST 2022, time=2022-08-16, status=1, ipAttribution=)]

相关资讯

香菜党福音?香菜籽臭是臭了点,但抗癌是真香!

芫荽籽多酚提取物有安全抗白血病潜力!

Oncotarget:六种植物提取物具有强大抗衰老作用

最近在国际著名期刊Oncotarget杂志上发表一项新研究中,来自加拿大康考迪亚大学和Idunn Technologies Inc的研究人员,揭示了一个重要的因素:含有六组抗衰老分子的植物提取物。 在这项研究中,研究小组对Idunn Technologies Inc广泛的生物库进行了搜寻,进行了10000多项试验,来筛选能延长酵母时序寿命的植物提取物。 为什么选用酵母?从细胞学上来说,衰老

JAMA:大样本数据证实植物提取物有效减轻更年期症状

之前一些相关研究发现,一些以植物为基础的疗法,其中有大豆提取的化合物,可能帮助缓解更年期症状。但是科学家们在近期的美国医学协会杂志发行的期刊JAMA中,用更严密的研究来证实了他们的结论。之前一些相关研究发现,一些以植物为基础的疗法,其中有大豆提取的化合物,可能帮助缓解更年期症状。但是科学家们需要更严密的研究来证实他们的结论。在近期的美国医学协会杂志发行的期刊JAMA中,科学家们分析了62组调查研究

Oncotarget:特殊的植物提取物或可使人永葆青春

发表于国际杂志Oncotarget上的一项研究论文中,来自Idunn科技的研究人员通过研究发现,植物中特殊的提取物或具有抗衰老的作用;文章中研究人员结合他们公司当前的生物学文库,同时开展了1万多种试验,最终筛选出了一种可以增加酵母寿命的新型植物提取物。那么就会有人问,为什么是酵母呢?因为酵母和人类机体中的老化进展非常相似,而且酵母是最佳的细胞模型来帮助我们研究机体抗衰老过程的发生机制。研究人员发现

Oncotarget:6类植物提取物能够延缓衰老

不老泉”也许只是一个传说,但这从未阻止科学家们寻找科学地获得“长生”的脚步。近年来,研究者们对rapamycin、metformin等药物的兴趣浓厚,主要在于它们能够有效地延长寿命并且有治疗疾病的能力。然而,最近一项研究表明这些药物的抗衰老能力已经不再独树一帜了:一些植物提取物含有目前已知最强的抗衰老特性。来自加拿大Concordia大学的研究者们进行了10000多次筛选试验,看那些植物提取物能够