Acta Neuropathologica:CDKN2A / B纯合子缺失与脑膜瘤的早期复发有关

2020-07-20 MedSci原创 MedSci原创

大多数高级脑膜瘤表现出高度干扰的拷贝数分布,并且富含TERT启动子突变。另外,在间变性脑膜瘤中观察到位于9p21的细胞周期蛋白依赖性激酶抑制剂2A(CDKN2A)基因的纯合子灶性缺失。作者本文调研52

大多数高级脑膜瘤表现出高度干扰的拷贝数分布,并且富含TERT启动子突变。另外,在间变性脑膜瘤中观察到位于9p21的细胞周期蛋白依赖性激酶抑制剂2A(CDKN2A)基因的纯合子灶性缺失。作者本文调研528名脑膜瘤患者队列中CDKN2A / B状况在总体预后中的作用,并提供临床随访数据,涵盖所有WHO等级和各种亚型。 主要内容在WHO分级,TERT启动子突变状态和基于DNA甲基化的分类的背景下评估CDKN2A / B状态的预测能力。

方法:从多个国际合作中心的档案中获得了528例患者的肿瘤组织和临床随访数据,并在海德堡大学医院神经病理学系(德国海德堡)中进行了收集。使用Infinium MethylationEPIC(850k),BeadChip(Illumina,San Diego,CA,USA)阵列进行肿瘤的DNA甲基化分析和拷贝数分析。通过Kaplan–Meier方法估算手术后进展(通过影像学确定)或复发(TTP)的时间分布,并将各组之间的对数秩检验进行比较。

结果:CDKN2A / B的纯合缺失在脑膜瘤中具有较高的预后性,对于这些肿瘤的分级可能是有用的,独立的分子生物标志物。

原文链接:Sievers, P., Hielscher, T., Schrimpf, D. et al. CDKN2A/B homozygous deletion is associated with early recurrence in meningiomasActa Neuropathol (2020). https://doi.org/10.1007/s00401-020-02188-w

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    2021-05-27 windight
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    2021-07-01 yb6560
  5. [GetPortalCommentsPageByObjectIdResponse(id=1849984, encodeId=01c81849984e5, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Thu May 27 11:23:31 CST 2021, time=2021-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786652, encodeId=18901e866525f, content=<a href='/topic/show?id=1c5d13e9171' target=_blank style='color:#2F92EE;'>#pathologic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13791, encryptionId=1c5d13e9171, topicName=pathologic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0cd7162, createdName=nakerunner, createdTime=Tue Jan 26 10:23:31 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756998, encodeId=84e11e56998ff, content=<a href='/topic/show?id=929f5936375' target=_blank style='color:#2F92EE;'>#早期复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59363, encryptionId=929f5936375, topicName=早期复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5bd37287806, createdName=124985dbm18(暂无昵称), createdTime=Mon Jun 07 11:23:31 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786358, encodeId=a36b1e8635857, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Jul 01 12:23:31 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280858, encodeId=a39e1280858a1, content=<a href='/topic/show?id=a55385062c7' target=_blank style='color:#2F92EE;'>#脑膜瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85062, encryptionId=a55385062c7, topicName=脑膜瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Wed Jul 22 14:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435545, encodeId=504e143554556, content=<a href='/topic/show?id=09dc439915' target=_blank style='color:#2F92EE;'>#CDK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4399, encryptionId=09dc439915, topicName=CDK)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jul 22 14:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803617, encodeId=401880361e56, content=好文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue Jul 21 05:28:34 CST 2020, time=2020-07-21, status=1, ipAttribution=)]
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    2020-07-22 zhouqu_8
  7. [GetPortalCommentsPageByObjectIdResponse(id=1849984, encodeId=01c81849984e5, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Thu May 27 11:23:31 CST 2021, time=2021-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786652, encodeId=18901e866525f, content=<a href='/topic/show?id=1c5d13e9171' target=_blank style='color:#2F92EE;'>#pathologic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13791, encryptionId=1c5d13e9171, topicName=pathologic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0cd7162, createdName=nakerunner, createdTime=Tue Jan 26 10:23:31 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756998, encodeId=84e11e56998ff, content=<a href='/topic/show?id=929f5936375' target=_blank style='color:#2F92EE;'>#早期复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59363, encryptionId=929f5936375, topicName=早期复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5bd37287806, createdName=124985dbm18(暂无昵称), createdTime=Mon Jun 07 11:23:31 CST 2021, time=2021-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786358, encodeId=a36b1e8635857, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Jul 01 12:23:31 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280858, encodeId=a39e1280858a1, content=<a href='/topic/show?id=a55385062c7' target=_blank style='color:#2F92EE;'>#脑膜瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85062, encryptionId=a55385062c7, topicName=脑膜瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Wed Jul 22 14:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435545, encodeId=504e143554556, content=<a href='/topic/show?id=09dc439915' target=_blank style='color:#2F92EE;'>#CDK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4399, encryptionId=09dc439915, topicName=CDK)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jul 22 14:23:31 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803617, encodeId=401880361e56, content=好文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue Jul 21 05:28:34 CST 2020, time=2020-07-21, status=1, ipAttribution=)]
    2020-07-21 njwbhuang

    好文章,学习了

    0

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