Neurology:老年人群白质高信号与下肢功能异常的相关性

2018-03-10 zhangfan MedSci原创

研究认为基线以及随访过程中白质高信号与老年人下肢功能异常相关,其相关性可通过SPPB得分进行评估,具有一定的临床价值

近日研究人员考察了存在记忆衰退的非痴呆老年人群,白质高信号(WMH)与3年内下肢功能异常(LEF)之间的关系。

58名70岁以上老人参与研究,对其进行MRI考察,平均随访963天。利用SPPB评估参与者下肢功能,使用混合效应线性回归考察SPPB分数与WMH体积之间的关系。二次分析中研究人员根据参与者WMH体积分层,考察WMH与下肢功能异常进展之间的关系。

研究发现,基线WMH体积(β = -0.017, 95% CI -0.025到-0.009)以及WMH病情加重(β = -0.002, 95% CI -0.003到-0.001)与SPPB得分降低相关。相比于基线WMH体积最低的1/4参与者,WMH体积最高的1/4参与者与SPPB得分下降的相关性显著(β = -0.301, 95% CI -0.558到-0.044),脑病变进展与SPPB得分下降相关。SPPB分数具有一定的临床意义,得分较高患者的WMH进展缓慢,约24-36个月。

研究认为基线以及随访过程中白质高信号与老年人下肢功能异常相关,其相关性可通过SPPB得分进行评估,具有一定的临床价值。

原始出处:


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    2018-10-01 yinhl1978
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  5. 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createdName=龙胆草, createdTime=Sat Mar 10 09:15:02 CST 2018, time=2018-03-10, status=1, ipAttribution=)]
    2018-03-18 虈亣靌

    优质资源.共同学习

    0

  7. 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    2018-03-10 龙胆草

    学习谢谢分享

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