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JCEM：阻塞性睡眠呼吸暂停可增加骨质疏松风险

2014-04-29 佚名 dxy

阻塞性睡眠呼吸骨质疏松风险
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阻塞性睡眠呼吸暂停（OSA）以反复发作的呼吸暂停/低通气和组织缺氧为特征，与代谢性疾病、内分泌疾病、以及心血管疾病有关。然而，OSA对骨代谢的影响仍不清楚。 为此，来自台湾奇美医学中心内分泌代谢科的Kai-Jen Tien教授及其团队进行了一项研究，探讨OSA与骨质疏松症之间可能存在的关系。该研究结果在线发表在2014年04月15日的The Journal of Clinical Endocri

阻塞性睡眠呼吸暂停（OSA）以反复发作的呼吸暂停/低通气和组织缺氧为特征，与代谢性疾病、内分泌疾病、以及心血管疾病有关。然而，OSA对骨代谢的影响仍不清楚。

为此，来自台湾奇美医学中心内分泌代谢科的Kai-Jen Tien教授及其团队进行了一项研究，探讨OSA与骨质疏松症之间可能存在的关系。该研究结果在线发表在2014年04月15日的The Journal of Clinical Endocrinology and Metabolism杂志上。

该研究中，Kai-Jen Tien教授等从台湾全民健康保险数据库中收集一个含1百万人的随机样本。2000年至2008年期间，共从这个随机样本中招募了1377例新诊断OSA患者，并与20655例无OSA受试者组成的匹配队列进行比较。对所有受试者进行跟踪，直至2011年末，期间若受试者被诊断为骨质疏松，或者受试者死亡，跟踪结束。

该研究发现，6年随访期间，OSA组和对照组中骨质疏松症发病率分别为每1000人年2.52和1.00。校正年龄、性别、糖尿病、高血压、冠心病、肥胖、卒中、高脂血症、慢性肾脏疾病、通风、每月收入和地域后，发现OSA患者骨质疏松症风险比无OSA患者高2.74倍。亚组分析显示老年患者骨质疏松症风险高于年轻患者，女性患者骨质疏松症风险高于男性患者。Log–rank分析显示OSA患者骨质疏松症累积发病率显著高于对照组患者。

该研究提示，OSA患者将来发生骨质疏松症的风险增加。Kai-Jen Tien教授提醒临床医师在治疗OSA患者时应注意到这种关系。同时，Kai-Jen Tien教授建议进行进一步的研究，评估OSA影响骨代谢的潜在机制。

原始链接

Chen YL1, Weng SF, Shen YC, Chou CW, Yang CY, Wang JJ, Tien KJ.Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan.J Clin Endocrinol Metab. 2014 Apr 15

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    2014-08-09 smallant2015

    #JCEM#

    0

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    2014-05-27 achengzhao

    #JCE#

    0

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    2014-05-22 zhanfl

    #睡眠呼吸#

    0

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    2014-07-24 tomyang96

    #阻塞#

    0

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    2014-05-01 Eleven17

    #骨质#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777470, encodeId=0d9a1e77470f7, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sat Aug 09 02:48:00 CST 2014, time=2014-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062851, encodeId=93e32062851f4, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue May 27 01:48:00 CST 2014, time=2014-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988974, encodeId=c1e619889e480, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Thu May 22 22:48:00 CST 2014, time=2014-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696629, encodeId=dbf2169662953, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Thu Jul 24 02:48:00 CST 2014, time=2014-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592269, encodeId=eb2e159226958, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Thu May 01 05:48:00 CST 2014, time=2014-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596433, encodeId=f93815964331c, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Thu May 01 05:48:00 CST 2014, time=2014-05-01, status=1, ipAttribution=)]
    2014-05-01 119337463

    #呼吸暂停#

    0