J Clin Periodontol:牙周炎和非酒精性脂肪肝疾病的关系:一项基于人群的健康调查研究

2017-08-17 MedSci MedSci原创

非酒精性脂肪肝疾病(NAFLD)使20-30%的成年人承受着罹患慢性低度炎症的风险,如:肥胖和胰岛素抗药性。由于牙周炎可以引发低度炎症,研究者推测:牙周炎可能会促使NAFLD发生。为此,这项研究的目的是通过对波美拉尼亚地区2,623名参与者进行健康调查,分析牙周炎与NAFLD发生率之间的流行病学联系。

非酒精性脂肪肝疾病(NAFLD)使20-30%的成年人承受着罹患慢性低度炎症的风险,如:肥胖和胰岛素抗药性。由于牙周炎可以引发低度炎症,研究者推测:牙周炎可能会促使NAFLD发生。为此,这项研究的目的是通过对波美拉尼亚地区2,623名参与者进行健康调查,分析牙周炎与NAFLD发生率之间的流行病学联系。

项目开始前对牙周炎的确诊是通过发病部位的百分比(0%, 1-30%, ≥30%)确定:1) 临床附着水平(CAL) ≥3mm;2) 探诊袋深(PD) ≥4mm。偶发NAFLD的确诊是通过相对于肾脏超声显示明显的肝回声增强,并伴随隔膜不清晰或门静脉壁不见回声区。

平均7年的随访调查显示,存在605例偶发NAFLD病例,发病率为每1,000人-年32·5例。相对于CAL < 3mm的项目参与者,牙周炎发病部位百分比在1-<30%的参与者NAFLD发生率轻微上调,而≥30%的参与者NAFLD发生率中度上调(多变量调整发病比率= 1.28, 95% CI, 0.84, 1.95和1·60, 95% CI, 1·05-2·43)。而在指标PD中未发现相似的剂量-反应关系。

结论:牙周炎发病史可能是引起NAFLD发生的一个风险因素。

原始出处:

Akinkugbe AA, Slade GD, et al. Periodontitis and Non-alcoholic Fatty Liver Disease, a population based cohort investigation in the Study of Health in Pomerania. J Clin Periodontol. 2017 Aug 14. doi: 10.1111/jcpe.12800.

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encodeId=758b2343e7d6, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Aug 17 09:55:32 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234348, encodeId=e4ea23434813, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Aug 17 08:35:15 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234338, encodeId=bf1b234338e0, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 17 08:16:11 CST 2017, time=2017-08-17, status=1, ipAttribution=)]
    2017-08-18 1e10c84am36(暂无匿称)

    文章很好,赞赞赞

    0

  8. 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encodeId=758b2343e7d6, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Aug 17 09:55:32 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234348, encodeId=e4ea23434813, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Aug 17 08:35:15 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234338, encodeId=bf1b234338e0, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 17 08:16:11 CST 2017, time=2017-08-17, status=1, ipAttribution=)]
    2017-08-17 131****1460

    学习了受益匪浅。

    0

  9. 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encodeId=758b2343e7d6, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Aug 17 09:55:32 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234348, encodeId=e4ea23434813, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Aug 17 08:35:15 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234338, encodeId=bf1b234338e0, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Aug 17 08:16:11 CST 2017, time=2017-08-17, status=1, ipAttribution=)]
    2017-08-17 李东泽

    很好,不错,以后会多学习

    0

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    2017-08-17 Y—xianghai

    学习了新知识

    0

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