Diabetes:长期高血糖可诱发龋齿,但不会导致牙周炎。

2017-08-11 qinqiyun MedSci原创

牙周病(PD)是糖尿病患者的第六位好发的并发症。研究人员已用糖尿病啮齿类动物模型证明糖尿病会增加龋齿,而溃疡性炎症可能会对邻近周围组织有强烈影响。但是,尚不能完全排除高血糖可诱发糖尿病动物患PD的可能性。本研究的目的是通过预防溃疡性炎症及氟化物的管理,来验证PD是否在糖尿病动物模型中存在。注射四氧嘧啶的F344大鼠(1型糖尿病模型)和db/db小鼠(2型糖尿病模型),分别给予自来水或含氟的自来水。

牙周病(PD)是糖尿病患者的第六位好发的并发症。研究人员已用糖尿病啮齿类动物模型证明糖尿病会增加龋齿,而溃疡性炎症可能会对邻近周围组织有强烈影响。

但是,尚不能完全排除高血糖可诱发糖尿病动物患PD的可能性。本研究的目的是通过预防溃疡性炎症及氟化物的管理,来验证PD是否在糖尿病动物模型中存在。

注射四氧嘧啶的F344大鼠(1型糖尿病模型)和db/db小鼠(2型糖尿病模型),分别给予自来水或含氟的自来水。氟化物预防龋齿的效果在糖尿病动物模型上很显着。同时,用氟化物治疗可抑制龋齿,并可以彻底消除牙周炎。此外,用氟化物治疗,正常的磨牙周围组织中均没有炎症,但是在牙齿形成过程中,明显观察到牙齿持续被牙周炎包绕,提示恶化的牙周炎症可能起源于糖尿病啮齿动物的龋齿而不是由PD引起的。

总而言之,在I型和II型糖尿病啮齿动物模型上,长期高血压会自然引发龋齿,但均没有牙周炎。

原始出处:

Yutaka Nakahara,Kiyokazu Ozaki and Tetsuro Matsuura.Long-term Hyperglycemia Naturally Induces Dental Caries But Not Periodontal Disease in Type-1 and Type-2 Diabetic Rodents.Diabetes.August 09,2017.https://doi.org/10.2337/db17-0291

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    2017-08-13 hbwxf
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    2017-08-11 131****1460

    学习了受益匪浅。

    0

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    2017-08-11 189****7206

    学习了受益匪浅

    0

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