J Dermatolog Treat:局部曲安奈德联合富血小板血浆可更好地治疗瘢痕疙瘩

2022-04-15 sunshine MedSci原创

瘢痕疙瘩是皮肤损伤后或自发发生的良性纤维增生,存在于易感人群的瘢痕组织中,通常不会自发恢复,并且在切除后容易复发。它们是由皮肤损伤后不规则的伤口愈合造成的,但有时也会自发发生。

瘢痕疙瘩是皮肤损伤后或自发发生的良性纤维增生,存在于易感人群的瘢痕组织中,通常不会自发恢复,并且在切除后容易复发。它们是由皮肤损伤后不规则的伤口愈合造成的,但有时也会自发发生。瘢痕疙瘩通常有瘙痒和疼痛,大大影响患者的生活质量。局部曲安奈德(TA)是其一线疗法,但通常与副作用或复发有关。富含血小板的血浆(PRP)是一种自体血源产品,在改善伤口愈合和降低瘢痕疙瘩发生率方面具有良好的效果。近日,发表于J Dermatolog Treat的一项随机试验评估和比较了TA和PRP联合皮内注射VS. TA单独注射在治疗瘢痕疙瘩方面的疗效。

研究共纳入40名瘢痕疙瘩患者,随机分为两组(A和B)。两组均接受皮内注射TA(20mg/ml),共4次,间隔3周。A组患者在TA注射后1周接受额外的PRP注射。随访3个月后,通过温哥华疤痕量表(VSS)和口头评分表(VRS)对疼痛和瘙痒进行了评估。

 

结果显示,与基线相比,两组患者的VSS和VRS的所有参数都有明显改善。此外,A组患者在瘢痕高度、色素沉着、柔韧度和总体VSS方面有明显的改善。在患者满意度方面,A组有65%的患者对治疗效果表示满意,35%的患者不满意,而B组有55%的患者表示满意,45%的患者不满意,两组之间无统计学差异。

综上所述,该研究结果表明,在瘢痕疙瘩的治疗中,将PRP与TA结合起来可以产生更好的美容效果,同时降低TA引起的副作用,特别是萎缩和色素减退的发生率。

 

原始出处:

 

El-Sayed Shaaban Hewedy, et al., Combined intralesional triamcinolone acetonide and platelet rich plasma versus intralesional triamcinolone acetonide alone in treatment of keloids. J Dermatolog Treat. 2022 Feb;33(1):150-156. doi: 10.1080/09546634.2020.1730742. 

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    2022-12-22 gujh
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    2022-04-13 chg122

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JAMA:注射曲安奈德可造成膝骨关节炎患者的软骨体积损失?

2017年5月,发表在《JAMA》的一项由美国科学家进行的随机临床试验,考察了关节腔内注射曲安奈德vs生理盐水对膝骨关节炎患者的膝关节软骨体积和疼痛的影响。

曲安奈德联合抗VEGF药物球内注射治疗脉络膜结核瘤1例

患者男性,18岁。因左眼视力下降伴视物变形1个月就诊,