Clin Gastroenterol H:降低炎症性肠病患者再住院率的危险因素和干预措施

2019-09-04 xing.T MedSci原创

由此可见,对于接受IBD治疗的患者,30天和90天再入院率分别为18.1%和26.0%。IBD急性发作和感染是再入院的常见原因,疼痛控制不足和需要肠外营养是常见的危险因素。需要进行干预性研究以降低再入院风险。

近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员调查了接受治疗的炎症性肠病(IBD)患者30天和90天再入院率、原因、危险因素和干预措施,以减少这些患者的再入院率。

研究人员对2018年7月1日的之前发表的文献进行了系统检索,这些研究中的IBD患者接受药物治疗,并且报道了再入院率和相关原因及危险因素。研究人员的最终分析纳入了17项在接受过治疗的IBD住院成人中进行的队列研究(6324名患者),这些研究报告了再入院率和详细的病例评估。研究人员进行了随机效应荟萃分析,以估计30天和90天的再入院率,并确定与再入院相关的原因和危险因素。研究人员还对研究进行了定性分析,重点是减少再入院的干预措施。

总体而言,30天再入院率为18.1%(95%CI为14.4-22.4),90天再入院率为26.0%(95%CI为22.7-29.6)。在meta回归方面,溃疡性结肠炎患者比克罗恩病患者的研究报告了更高的再入院风险。再入院的最常见原因是IBD急性发作、感染或住院期间意外手术引起的并发症。30天再入院的危险因素是疼痛控制入院(比值比[OR]为2.27; 95%CI为1.69-3.03)、出院时需要全肠外营养(OR为2.13; 95%CI为1.36-3.35)以及入院时的计划或计划外手术(OR为3.11; 95%CI为2.27-4.25)。只有一项研究侧重于干预措施(专门的住院IBD服务),以降低再入院的风险。

由此可见,对于接受IBD治疗的患者,30天和90天再入院率分别为18.1%和26.0%。IBD急性发作和感染是再入院的常见原因,疼痛控制不足和需要肠外营养是常见的危险因素。需要进行干预性研究以降低再入院风险。 

原始出处:

Nghia H. Nguyen,et al.Rate of, Risk Factors for, and Interventions to Reduce Hospital Readmission in Patients with Inflammatory Bowel Diseases.Clinical gastroenterology and hepatology.2019.https://www.cghjournal.org/article/S1542-3565(19)30917-6/fulltext

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由此可见,基于人群的美国成人糖尿病队列研究表明,短期DPP4i治疗不会增加IBD风险。

GUT:肾素-血管紧张素系统(RAS)与炎症性肠病

研究认为RAS介导人类细胞的纤维化并在肠道炎症中受到干扰,靶向该系统的药物与改善疾病结局有关

JAMA Pediatr:患炎症性肠病的儿童患精神疾病的风险增加

根据瑞典Karolinska研究所发表于JAMA Pediatrics的一项新研究显示,患有炎症性肠病(IBD)的儿童患精神疾病的风险更大。