JCLA：基于液相色谱-串联质谱检测多囊卵巢综合征女性与胰岛素抵抗的关系

2019-07-14 Gladiator MedSci原创

本研究采用液相色谱-串联质谱法(LC‐MS/MS)测定血清总睾酮(TT)，探讨多囊卵巢综合征(PCOS)患者高雄激素血症(HA)与胰岛素抵抗(IR)的相关性。本队列研究包括332例PCOS患者、63例IR患者和276例对照患者。用LC‐MS/MS和化学发光免疫分析法(CLIA)测定TT水平，同时，由口服葡萄糖耐量试验(OGTT)测定葡萄糖和胰岛素水平。与CLIA相比，LC MS / MS可区别更多

本研究采用液相色谱-串联质谱法(LC‐MS/MS)测定血清总睾酮(TT)，探讨多囊卵巢综合征(PCOS)患者高雄激素血症(HA)与胰岛素抵抗(IR)的相关性。
本队列研究包括332例PCOS患者、63例IR患者和276例对照患者。用LC‐MS/MS和化学发光免疫分析法(CLIA)测定TT水平，同时，由口服葡萄糖耐量试验(OGTT)测定葡萄糖和胰岛素水平。
与CLIA相比，LC MS / MS可区别更多高TT水平的病例，与没有胰岛素抵抗相比，基于LC- MS / MS检测TT水平或结合mFG评分可在高胰岛素血症(HIN)、HOMA IR或空腹血糖受损(IFG)确认的胰岛素抵抗病例中检测到更高比率的高雄激素血症。在LC MS/MS定义的高TT亚组中，HIN、HOMA IR或IFG定义的胰岛素抵抗组显著高于正常TT亚组。然而，CLIA平台不能IR组和非IR组之间的HA发生率，以及较高和正常TT人群之间的IR率的差异。ROC曲线也证明，经LC‐MS/MS测定，HIN、HOMA‐IR和IFG对HA有正向贡献。
原始出处：

Yabo Yang ,Miao Ding ,Close correlation between hyperandrogenism and insulin resistance in women with polycystic ovary syndrome—Based on liquid chromatography with tandem mass spectrometry measurements

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2019-10-24 baoya

#胰岛#

26 0
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2019-10-23 kalseyzl

#多囊卵巢#

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2019-07-16 zhouqu_8

#综合征#

28 0
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2019-07-16 jeanqiuqiu

#质谱#

38 0
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2019-07-15 122e052cm96暂无昵称

好

77 0
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2019-07-15 1209e435m98(暂无昵称)

学习了，谢谢分享

65 0
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2019-07-15 phoebeyan520

学习了

66 0

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