JCO: DRC独立预测NSCLC患者生存

2011-10-04 MedSci原创 MedSci原创

  美国一项研究表明,外周血淋巴细胞DNA修复能力(DRC)是接受以铂类为基础化疗的非小细胞肺癌(NSCLC)患者生存状况的独立预测因素。研究论文9月26日在线发表于《临床肿瘤学杂志》(J Clin Oncol)。   该研究共纳入了德克萨斯大学MD安德森癌症中心的591例NSCLC患者,并在化疗前采集患者血液样本。研究采用宿主细胞再活化检测法在体外培养的T淋巴细胞中检测DR

  美国一项研究表明,外周血淋巴细胞DNA修复能力(DRC)是接受以铂类为基础化疗的非小细胞肺癌NSCLC)患者生存状况的独立预测因素。研究论文9月26日在线发表于《临床肿瘤学杂志》(J Clin Oncol)。

  该研究共纳入了德克萨斯大学MD安德森癌症中心的591例NSCLC患者,并在化疗前采集患者血液样本。研究采用宿主细胞再活化检测法在体外培养的T淋巴细胞中检测DRC,并评估外周血淋巴细胞DRC与接受铂类为基础一线化疗的NSCLC患者生存状况的相关性。

  结果显示,外周血淋巴细胞DRC与患者生存率之间呈负相关性。与DRC为最低三分位者相比,DRC为最高三分位的NSCLC患者总生存率和3年生存率显著降低,这一趋势在早期肿瘤、腺癌和鳞状细胞癌患者中更为明显。

  相关链接:DNA Repair Capacity in Peripheral Lymphocytes Predicts Survival of Patients With Non–Small-Cell Lung Cancer Treated With First-Line Platinum-Based Chemotherapy

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    2015-09-27 hassan

    The'res nothing like the relief of finding what you're looking for.

    0

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    2012-08-24 jklm09
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    2012-08-03 lidong40
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