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J Photochem Photobiol B：中性卟啉衍生物的抗菌效果如何？

2018-06-30 MedSci MedSci原创

关注

https://www.ncbi.nlm.nih.gov/pubmed/29951316

以来一直带正电荷的卟啉被认为是有效的杀生物剂，然而很少有研究探究了中性卟啉的光灭活微生物的能力，并且电子效应与卟啉的杀生物活性的相关性等结构-活性关系仍不清楚。在此，选择具有各种电子效应的四种中性卟啉进行光致生物杀灭过程。

结果表明，具有给电子基团NH2和OH的TPPOH和TPPNH 2分别比具有吸电子基团NO2的TPP和TPPNO 2对大肠杆菌和金黄色葡萄球菌表现出更强的光诱导杀生物活性。这一现象表明，中性卟啉可作为一类新的抗菌剂，且卟啉的各种官能团可明显影响卟啉的光诱导的杀生物活性。

机制研究表明，尽管TPPOH具有较好的光诱导抗菌能力，但其单线态氧的产生效率略低于TPPNH2，且具有电荷特性和亲油性，因此很清楚：（1）氧化态单线态氧和ROS （2）TPPOH和TPPNH2的单线态氧或ROS产率较高可能源于其结构特征，即给电子基团OH或NH2，和（3）协同作用包括静电效应和疏水效应在内的所有其他因素的影响都必须涉及该过程并协同发挥其抗菌活性。

原始出处：

Wang J, Yang X, et al., Visible light-induced biocidal activities and mechanistic study of neutral porphyrin derivatives against S. aureus and E. coli. J Photochem Photobiol B. 2018 Jun 26;185:199-205. doi: 10.1016/j.jphotobiol.2018.06.003.

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    2018-08-02 12498ebem31暂无昵称

    #Biol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1767471, encodeId=60af1e67471ba, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Aug 02 21:56:00 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788727, encodeId=dca61e8872737, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Fri Dec 28 03:56:00 CST 2018, time=2018-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812671, encodeId=434818126e178, content=<a href='/topic/show?id=d193900940b' target=_blank style='color:#2F92EE;'>#衍生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90094, encryptionId=d193900940b, topicName=衍生物)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Aug 19 14:56:00 CST 2018, time=2018-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918168, encodeId=073f191816819, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 17 14:56:00 CST 2018, time=2018-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330753, encodeId=edd91330e531c, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Mon Jul 02 14:56:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593792, encodeId=87521593e922c, content=<a href='/topic/show?id=186755696e6' target=_blank style='color:#2F92EE;'>#抗菌效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55696, encryptionId=186755696e6, topicName=抗菌效果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05b918160916, createdName=DEXTER3145, createdTime=Mon Jul 02 14:56:00 CST 2018, time=2018-07-02, status=1, ipAttribution=)]
    2018-12-28 liuxiaona

    #photo#

    0

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    2018-08-19 仁心济世

    #衍生物#

    0

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    2018-07-17 sunylz

    #Bio#

    0

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    2018-07-02 ms7899726347904398

    #抗菌#

    0

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    2018-07-02 DEXTER3145

    #抗菌效果#

    0