Ann Clin Transl Neurol：CXCR4受体激动剂可在坐骨神经损伤后刺激轴突的再生

2020-10-02 MedSci原创 MedSci原创

本研究旨在检验坐骨神经被挤压/切割后信号轴CXCL12α-CXCR4是否被激活，并检验新型CXCR4激动剂NUCC-390在促进神经损伤恢复方面的活性，研究结果已在线发表于Ann Clin

本研究旨在检验坐骨神经被挤压/切割后信号轴CXCL12α-CXCR4是否被激活，并检验新型CXCR4激动剂NUCC-390在促进神经损伤恢复方面的活性，研究结果已在线发表于Ann Clin Transl Neurol。

压碎或切断坐骨神经。通过特异性抗体成像评估CXCL12α和CXCR4的表达和定位。通过抗体中和CXCL12α，以及CXCR4特异性拮抗剂AMD3100，确定它们在神经再生中的功能，使用复合肌肉动作电位（CMAP）作为定量读出。通过成像和CMAP记录确定NUCC-390对神经再生的活性。

结果显示，CXCR4在轴突内的损伤部位表达，而其配体CXCL12α在施万细胞中表达。CXCL12α-CXCR4轴参与了受伤神经的神经传递的恢复。更重要的是，小分子NUCC-390通过与CXCL12α十分相似的作用，有力地促进了神经的功能和解剖学恢复。这种药理作用是由于NUCC-390在体外和体内都能促进运动神经元轴突的伸长。

综上所述，影像学和电生理学数据提供了新的和令人信服的证据，证明CXCL12α-CXCR4轴参与了粉碎/切割后的坐骨神经修复。这使得NUCC-390成为一个强有力的候选分子，通过促进轴突伸长来刺激神经修复。建议将该分子在其他神经元损伤模型中进行测试，为临床试验NUCC-390在人体周围神经修复中的疗效奠定基础。

原始出处：

Giulia Zanetti, Samuele Negro, et al., A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage. Ann Clin Transl Neurol. 2019 Dec;6(12):2395-2402. doi: 10.1002/acn3.50926.

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2020-11-03 bsmagic9140

#TRA#

36 0
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2021-07-23 yinhl1978

#Neurol#

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2021-08-26 ms3025846204744509

#Transl#

43 0
[GetPortalCommentsPageByObjectIdResponse(id=1657370, encodeId=e1a1165e3709c, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Nov 03 20:11:19 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001119, encodeId=507e2001119d4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 23 04:11:19 CST 2021, time=2021-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067520, encodeId=65e0206e5208a, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Aug 26 17:11:19 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398053, encodeId=b5d31398053ab, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412461, encodeId=4d311412461b0, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571816, encodeId=927215e1816fc, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584302, encodeId=5471158430210, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627838, encodeId=3775162e8389e, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
2020-10-04 ms3046638856685384

#损伤#

29 0
[GetPortalCommentsPageByObjectIdResponse(id=1657370, encodeId=e1a1165e3709c, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Nov 03 20:11:19 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001119, encodeId=507e2001119d4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 23 04:11:19 CST 2021, time=2021-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067520, encodeId=65e0206e5208a, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Aug 26 17:11:19 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398053, encodeId=b5d31398053ab, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412461, encodeId=4d311412461b0, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571816, encodeId=927215e1816fc, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584302, encodeId=5471158430210, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627838, encodeId=3775162e8389e, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
2020-10-04 chenwq09

#CXCR4#

39 0
[GetPortalCommentsPageByObjectIdResponse(id=1657370, encodeId=e1a1165e3709c, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Nov 03 20:11:19 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001119, encodeId=507e2001119d4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 23 04:11:19 CST 2021, time=2021-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067520, encodeId=65e0206e5208a, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Aug 26 17:11:19 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398053, encodeId=b5d31398053ab, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412461, encodeId=4d311412461b0, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571816, encodeId=927215e1816fc, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584302, encodeId=5471158430210, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627838, encodeId=3775162e8389e, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
2020-10-04 ycmayy

#坐骨神经#

34 0
[GetPortalCommentsPageByObjectIdResponse(id=1657370, encodeId=e1a1165e3709c, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Nov 03 20:11:19 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001119, encodeId=507e2001119d4, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 23 04:11:19 CST 2021, time=2021-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067520, encodeId=65e0206e5208a, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Aug 26 17:11:19 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398053, encodeId=b5d31398053ab, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412461, encodeId=4d311412461b0, content=<a href='/topic/show?id=c5d95546ff' target=_blank style='color:#2F92EE;'>#CXCR4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5546, encryptionId=c5d95546ff, topicName=CXCR4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c832868137, createdName=chenwq09, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571816, encodeId=927215e1816fc, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584302, encodeId=5471158430210, content=<a href='/topic/show?id=ee6de4320c6' target=_blank style='color:#2F92EE;'>#神经损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74320, encryptionId=ee6de4320c6, topicName=神经损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=771e17042997, createdName=LShY0906_98743849, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627838, encodeId=3775162e8389e, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sun Oct 04 12:11:19 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
2020-10-04 LShY0906_98743849

#神经损伤#

0 0
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2020-10-04 medscijoin

#激动剂#

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Ann Clin Transl Neurol：CXCR4受体激动剂可在坐骨神经损伤后刺激轴突的再生

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