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Chest：波生坦能显著改善结节病相关性肺动脉高压患者的肺血流动力学

2013-11-22 sd3212 丁香园

Chest：波生坦肺动脉
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结节病相关性肺动脉高压(SAPH)是结节病患者出现持续性呼吸困难的一个常见原因。为了明确波生坦（bosentan）治疗对SAPH患者肺动脉血流动力学的影响，来自美国俄亥俄州辛辛那提大学医学中心内科的 Robert P. Baughman博士及其同事进行了一项研究，研究结果在线发表于2013年10月31日的CHEST杂志上。研究结果显示：波生坦能显著改善SAPH患者的肺血流动力学。该研究是一项为期1

结节病相关性肺动脉高压(SAPH)是结节病患者出现持续性呼吸困难的一个常见原因。为了明确波生坦（bosentan）治疗对SAPH患者肺动脉血流动力学的影响，来自美国俄亥俄州辛辛那提大学医学中心内科的 Robert P. Baughman博士及其同事进行了一项研究，研究结果在线发表于2013年10月31日的CHEST杂志上。研究结果显示：波生坦能显著改善SAPH患者的肺血流动力学。

该研究是一项为期16周的双盲、安慰剂对照临床研究。其研究对象主要是经右心导管检查证实的SAPH患者。研究在美国多个结节病专业医疗中心进行。

所有受试者在入组前均处于接受结节病稳定期治疗的状态；而且，其均被证实患有肺动脉高压，但尚未接受针对肺动脉高压的治疗。研究者按照2:1的比例，将上述受试者随机分为两组，并分别给予其连续16周的波生坦或安慰剂治疗。其中，波生坦的用法为：以125mg的最大剂量，每天两次口服。研究者监测并评估了受试者接受研究性治疗前、后的肺功能、6分钟步行试验、及右心血流动力学状态等指标。其中，检测的右心血流动力学指标主要包括肺动脉平均压（PAm）、和肺血管阻力(PVR) 等。

该研究的主要结果为：共有35名受试者完成了16周的治疗。其中，波生坦组21人，安慰剂组12人。经过16周研究性治疗后的右心血液动力学复查结果显示：波生坦组患者的Pam、和PVR较治疗前分别有了一个平均-4毫米汞柱、和-1.7 Wood单位的显著下降；而安慰剂组患者的PAm、和PVR较治疗前的平均改变分别为1毫米汞柱、和0.1 Wood单位，与治疗前相比均无统计学意义上的显著差异。此外，两组受试者的6分钟步行试验结果在治疗前、后均无显著性变化。而两名波生坦组受试者在完成16周的治疗后，其供氧流量需要较治疗前增加2升/分钟以上。

该研究结果显示：波生坦能显著改善结节病相关性肺动脉高压患者的肺血流动力学。

该研究已在临床试验网（ClinTrials）注册，其注册号为：NCT00581607。

原文出处

Baughman RP, Culver DA, Cordova FC, Padilla M, Gibson KF, Lower EE, Engel PJ.Bosentan for sarcoidosis associated pulmonary hypertension: A double-blind placebo controlled randomized trial.Chest. 2013 Oct 31. 

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    2014-06-12 jklm09

    #动脉高压#

    0

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    2014-01-17 仁心济世

    #血流动力#

    0

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    2014-03-15 naiwu77

    #肺动脉高压患者#

    0

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    2014-01-08 xiangyuzhou971

    #EST#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1925111, encodeId=2a78192511175, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Jun 12 19:37:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812022, encodeId=fcb81812022b0, content=<a href='/topic/show?id=d7a1891613d' target=_blank style='color:#2F92EE;'>#血流动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89161, encryptionId=d7a1891613d, topicName=血流动力)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Jan 17 23:37:00 CST 2014, time=2014-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808588, encodeId=7104180858805, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Mar 15 09:37:00 CST 2014, time=2014-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050382, encodeId=200d2050382cb, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Jan 08 15:37:00 CST 2014, time=2014-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837128, encodeId=31df183e1283d, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Sep 28 02:37:00 CST 2014, time=2014-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929199, encodeId=b97a1929199bc, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Sep 11 00:37:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391974, encodeId=fd6113919e419, content=<a href='/topic/show?id=3704891621c' target=_blank style='color:#2F92EE;'>#血流动力学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89162, encryptionId=3704891621c, topicName=血流动力学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Sun Nov 24 04:37:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
    2014-09-28 shenxlcyp

    #相关性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1925111, encodeId=2a78192511175, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Jun 12 19:37:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812022, encodeId=fcb81812022b0, content=<a href='/topic/show?id=d7a1891613d' target=_blank style='color:#2F92EE;'>#血流动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89161, encryptionId=d7a1891613d, topicName=血流动力)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Jan 17 23:37:00 CST 2014, time=2014-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808588, encodeId=7104180858805, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Mar 15 09:37:00 CST 2014, time=2014-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050382, encodeId=200d2050382cb, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Jan 08 15:37:00 CST 2014, time=2014-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837128, encodeId=31df183e1283d, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Sep 28 02:37:00 CST 2014, time=2014-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929199, encodeId=b97a1929199bc, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Sep 11 00:37:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391974, encodeId=fd6113919e419, content=<a href='/topic/show?id=3704891621c' target=_blank style='color:#2F92EE;'>#血流动力学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89162, encryptionId=3704891621c, topicName=血流动力学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Sun Nov 24 04:37:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
    2014-09-11 Smile2680

    #Chest#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1925111, encodeId=2a78192511175, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Thu Jun 12 19:37:00 CST 2014, time=2014-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812022, encodeId=fcb81812022b0, content=<a href='/topic/show?id=d7a1891613d' target=_blank style='color:#2F92EE;'>#血流动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89161, encryptionId=d7a1891613d, topicName=血流动力)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Jan 17 23:37:00 CST 2014, time=2014-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808588, encodeId=7104180858805, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Sat Mar 15 09:37:00 CST 2014, time=2014-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050382, encodeId=200d2050382cb, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Jan 08 15:37:00 CST 2014, time=2014-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837128, encodeId=31df183e1283d, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Sep 28 02:37:00 CST 2014, time=2014-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929199, encodeId=b97a1929199bc, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Sep 11 00:37:00 CST 2014, time=2014-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391974, encodeId=fd6113919e419, content=<a href='/topic/show?id=3704891621c' target=_blank style='color:#2F92EE;'>#血流动力学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89162, encryptionId=3704891621c, topicName=血流动力学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Sun Nov 24 04:37:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
    2013-11-24 zjshifan_98647306

    #血流动力学#

    0