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Dent Mater J：羟基磷灰石包裹改善TiO2纳米管表面的成骨细胞粘附和骨整合

2018-12-20 lishiting MedSci原创

钛HAAO/HA骨整合粘附
关注

这篇研究的目的是为了通过阳极氧化(AO)辅以额外的羟基磷灰石包裹构建钛(Ti)表面的TiO2纳米管图层以形成AO/HA表面。

这篇研究的目的是为了通过阳极氧化(AO)辅以额外的羟基磷灰石包裹构建钛(Ti)表面的TiO2纳米管图层以形成AO/HA表面。

体外细胞活性的检测显示，AO表面，特别是AO/HA表面，可以促进成骨细胞最初的粘附、增殖和分化。并且，改良AO和AO/HA表面可以上调成骨和粘附标志物的基因表达：I型胶原、骨桥蛋白(OPN)、骨钙素(OCN)和纽蛋白。另外，体内实验显示，AO表面、特别是AO/HA表面比Ti表现出更早的骨整合和更强的骨结合能力。

这些结果展示了纳米形貌和HA之间协同促进成骨细胞的粘附、增殖、分化和骨整合。结果代表了一种更有希望的改良种植体表面的方法。

原始出处：

Li Y， Li B， et al. Improved osteoblast adhesion and osseointegration on TiO2 nanotubes surface with hydroxyapatite coating. Dent Mater J. 2018 Dec 11. doi： 10.4012/dmj.2018-118.

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    2018-12-22 zhaojie88

    #成骨#

    0

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    2018-12-22 jj000004

    #骨细胞#

    0

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    2018-12-22 bnurmamat

    #骨整合#

    0

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    2018-12-22 爆笑小医

    #羟基磷灰石#

    0

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    2018-12-20 惠映实验室

    学习了，谢谢分享。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1351919, encodeId=230c135191927, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 22 13:26:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495111, encodeId=19bf149511170, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sat Dec 22 13:26:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521764, encodeId=96fd1521e64ef, content=<a href='/topic/show?id=0b8f101e026a' target=_blank style='color:#2F92EE;'>#骨整合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101702, encryptionId=0b8f101e026a, topicName=骨整合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03f111392267, createdName=bnurmamat, createdTime=Sat Dec 22 13:26:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622147, encodeId=f838162214ec2, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 22 13:26:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355970, encodeId=a4143559e0da, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Dec 20 23:34:24 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355966, encodeId=c7e635596688, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Dec 20 23:28:15 CST 2018, time=2018-12-20, status=1, ipAttribution=)]
    2018-12-20 天地飞扬

    了解一下，谢谢分享！

    0

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