Chest:肥胖在睡眠呼吸障碍及心脏手术后房颤中的效应调节作用

2017-06-10 xiangting MedSci原创

在未经调整的分析中SDB与PCSAF显著相关,但在考虑到肥胖后两者没有相关性。

目前睡眠呼吸障碍(SDB)、心脏手术后房颤(PCSAF)和肥胖之间的相互关系仍不明确,这项研究旨在基于临床队列探讨三者的相互关系。

纳入2009年1月至2014年1月期间,3年内多导睡眠监测和心脏手术(冠状动脉旁路手术和/或瓣膜手术)的患者,排除原有房颤的患者。使用Logistic模型确定SDB(呼吸暂停低通气指数[AHI] /每5个单位增加),和次级预测因子(中枢性睡眠呼吸暂停[CSA] [中枢呼吸暂停指数≥5]和氧饱和度指数[ODI])与PCSAF的关系。根据年龄、性别、种族、BMI和高血压调整模型。通过中位BMI计算数值相互作用和分层。计算ORs和95%CIs。

分析样本包括190例患者(平均年龄为60.6±11.4岁;女性为36.1%;80%为白人,BMI为33.3±7.5 kg / m2; 93.2%为AHI≥5; 30%有PCSAF)。与未经调整的分析不同(OR,1.06; 95%CI,1.01-1.1),在调整后的模型中,增加的AHI与PCSAF的比例增加并不显著相关(OR为1.04; 95%CI为0.98-1.1)。CSA和ODI均不与PCSAF相关。中位BMI存在显著的相互作用(P = 0.015)。中位BMI存在效果调节作用; BMI> 32 kg / m2的患者,PCSAF的几率增加了15%(OR为1.15; 95%CI为1.05-1.26; P <0.003)。

在未经调整的分析中SDB与PCSAF显著相关,但在考虑到肥胖后两者没有相关性。SDB和肥胖的患者可能PCSAF及其相关并发症的发病率低。

原始出处:

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topicList=[TopicDto(id=39730, encryptionId=95ea39e304e, topicName=呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02a536676444, createdName=bbwznl, createdTime=Wed Feb 14 21:18:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929355, encodeId=a34b1929355aa, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Feb 13 12:18:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209753, encodeId=aa78209e53a7, content=好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jun 12 08:47:42 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345574, encodeId=dc7413455e4c0, content=<a href='/topic/show?id=41b2e2996be' target=_blank style='color:#2F92EE;'>#睡眠呼吸障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72996, encryptionId=41b2e2996be, topicName=睡眠呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, 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  5. 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topicList=[TopicDto(id=39730, encryptionId=95ea39e304e, topicName=呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02a536676444, createdName=bbwznl, createdTime=Wed Feb 14 21:18:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929355, encodeId=a34b1929355aa, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Feb 13 12:18:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209753, encodeId=aa78209e53a7, content=好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jun 12 08:47:42 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345574, encodeId=dc7413455e4c0, content=<a href='/topic/show?id=41b2e2996be' target=_blank style='color:#2F92EE;'>#睡眠呼吸障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72996, encryptionId=41b2e2996be, topicName=睡眠呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209200, encodeId=63bb209200b6, content=学习了分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun Jun 11 06:59:18 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209083, encodeId=8cff2090830b, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sat Jun 10 19:53:27 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209046, encodeId=dc9520904655, content=谢谢分享,学习了,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 10 19:09:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2018-02-13 Smile2680
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sat Jun 10 19:53:27 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209046, encodeId=dc9520904655, content=谢谢分享,学习了,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 10 19:09:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-12 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!

    0

  7. 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topicList=[TopicDto(id=39730, encryptionId=95ea39e304e, topicName=呼吸障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=02a536676444, createdName=bbwznl, createdTime=Wed Feb 14 21:18:00 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929355, encodeId=a34b1929355aa, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Feb 13 12:18:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209753, encodeId=aa78209e53a7, content=好文,值得点赞,更值得收藏!慢慢领会学习的。给点个赞!, beContent=null, objectType=article, channel=null, level=null, 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  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sat Jun 10 19:53:27 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209046, encodeId=dc9520904655, content=谢谢分享,学习了,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 10 19:09:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-11 杨利洪

    学习了分享一下

    0

  9. 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createdTime=Mon Jun 12 06:18:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209200, encodeId=63bb209200b6, content=学习了分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun Jun 11 06:59:18 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209083, encodeId=8cff2090830b, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sat Jun 10 19:53:27 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209046, encodeId=dc9520904655, content=谢谢分享,学习了,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 10 19:09:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-10 184****9840

    学习了谢谢分享。

    0

  10. 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    2017-06-10 清风拂面

    谢谢分享,学习了,受益匪浅

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