Am J Med Sci:促红细胞生成素在糖皮质激素诱导的股骨头骨坏死中通过缺氧诱导因子信号通路增强骨修复作用

2018-06-20 MedSci MedSci原创

本研究旨在确定促红细胞生成素是否可以在全身或局部给予重组人促红细胞生成素后修复糖皮质激素诱导的股骨头坏死。 使用明胶微球载入重组人促红细胞生成素进行药物局部递送。将48只Wistar大鼠,包括糖皮质激素诱导的股骨头大鼠,随机分成安慰剂组、全身促红细胞生成素组和局部促红细胞生成素组。八周后,处死所有大鼠并将其组织进行影像学,组织学,免疫组化,定量聚合酶链式反应和蛋白质印迹分析。结果显示,与安慰剂相比

本研究旨在确定促红细胞生成素是否可以在全身或局部给予重组人促红细胞生成素后修复糖皮质激素诱导的股骨头坏死。

使用明胶微球载入重组人促红细胞生成素进行药物局部递送。将48只Wistar大鼠,包括糖皮质激素诱导的股骨头大鼠,随机分成安慰剂组、全身促红细胞生成素组和局部促红细胞生成素组。八周后,处死所有大鼠并将其组织进行影像学,组织学,免疫组化,定量聚合酶链式反应和蛋白质印迹分析。

结果显示,与安慰剂相比,使用重组人促红细胞生成素可增加骨量、小梁数量、小梁厚度和小梁分离度。促红细胞生成素给药可明显改善股骨头缺氧相关转录因子2、碱性磷酸酶、缺氧诱导因子-1α和血管内皮生长因子的表达。此外,我们还发现局部注射促红细胞生成素可以更好地介导缺氧诱导因子-1α控制的成骨和血管生成因子表达,并更好地修复糖皮质激素诱导的股骨头坏死。

综上所述,该研究结果表明,重组人促红细胞生成素可改善糖皮质激素诱导的股骨头坏死,上调缺氧相关转录因子2、碱性磷酸酶、缺氧诱导因子1α和血管内皮生长因子的表达。使用促红细胞生成素可以通过改善骨形成和血管生成来修复糖皮质激素诱导的股骨头坏死,并且可能与缺氧诱导因子-1α通路有关。使用明胶微球递送促红细胞生成素似乎值得推荐。

原始出处:

Li D, Hu Q, et al., Erythropoietin Enhances Bone Repair Effects via the Hypoxia-Inducible Factor Signal Pathway in Glucocorticoid-Induced Osteonecrosis of the Femoral Head. Am J Med Sci. 2018 Jun;355(6):597-606. doi: 10.1016/j.amjms.2018.03.010. Epub 2018 Mar 8.

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    2018-07-29 redcrab
  2. 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    2018-09-25 zll0634
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  4. 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  5. [GetPortalCommentsPageByObjectIdResponse(id=1721848, encodeId=96ca1e21848a8, content=<a href='/topic/show?id=01811016363e' target=_blank style='color:#2F92EE;'>#骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101636, encryptionId=01811016363e, topicName=骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cd033099978, createdName=redcrab, createdTime=Sun Jul 29 00:35:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680005, encodeId=d582168000505, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Tue Sep 25 03:35:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701224, encodeId=86dd1e012246d, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Sat Jul 14 08:35:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805929, encodeId=92aa18059291d, content=<a href='/topic/show?id=747de9336a7' target=_blank style='color:#2F92EE;'>#缺氧诱导因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1719487, encodeId=967e1e1948735, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Fri Jul 27 22:35:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326235, encodeId=90a432623574, content=很不错的文献, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150625/IMG558B8C995D7262168.jpg, createdBy=36ad1623080, createdName=cyzj007, createdTime=Sat Jun 23 00:25:49 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282005, encodeId=f8941282005ad, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362884, encodeId=81cc136288430, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1721848, encodeId=96ca1e21848a8, content=<a href='/topic/show?id=01811016363e' target=_blank style='color:#2F92EE;'>#骨头#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101636, encryptionId=01811016363e, topicName=骨头)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cd033099978, createdName=redcrab, createdTime=Sun Jul 29 00:35:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680005, encodeId=d582168000505, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Tue Sep 25 03:35:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701224, encodeId=86dd1e012246d, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Sat Jul 14 08:35:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805929, encodeId=92aa18059291d, content=<a href='/topic/show?id=747de9336a7' target=_blank style='color:#2F92EE;'>#缺氧诱导因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1719487, encodeId=967e1e1948735, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Fri Jul 27 22:35:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326235, encodeId=90a432623574, content=很不错的文献, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150625/IMG558B8C995D7262168.jpg, createdBy=36ad1623080, createdName=cyzj007, createdTime=Sat Jun 23 00:25:49 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282005, encodeId=f8941282005ad, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362884, encodeId=81cc136288430, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419951, encodeId=37a414199515d, content=<a href='/topic/show?id=c7d9e716941' target=_blank style='color:#2F92EE;'>#红细胞生成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77169, encryptionId=c7d9e716941, topicName=红细胞生成)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=489d3549369, createdName=许安, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-07-27 axin020
  7. 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createdBy=63ef27829166, createdName=zll0634, createdTime=Tue Sep 25 03:35:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701224, encodeId=86dd1e012246d, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Sat Jul 14 08:35:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805929, encodeId=92aa18059291d, content=<a href='/topic/show?id=747de9336a7' target=_blank style='color:#2F92EE;'>#缺氧诱导因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1719487, encodeId=967e1e1948735, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Fri Jul 27 22:35:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326235, encodeId=90a432623574, content=很不错的文献, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150625/IMG558B8C995D7262168.jpg, createdBy=36ad1623080, createdName=cyzj007, createdTime=Sat Jun 23 00:25:49 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282005, encodeId=f8941282005ad, content=<a href='/topic/show?id=3dece71531e' target=_blank style='color:#2F92EE;'>#红细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77153, encryptionId=3dece71531e, topicName=红细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c22f171, createdName=kord1982, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362884, encodeId=81cc136288430, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419951, encodeId=37a414199515d, content=<a href='/topic/show?id=c7d9e716941' target=_blank style='color:#2F92EE;'>#红细胞生成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77169, encryptionId=c7d9e716941, topicName=红细胞生成)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=489d3549369, createdName=许安, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-06-23 cyzj007

    很不错的文献

    0

  8. 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  9. 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authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419951, encodeId=37a414199515d, content=<a href='/topic/show?id=c7d9e716941' target=_blank style='color:#2F92EE;'>#红细胞生成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77169, encryptionId=c7d9e716941, topicName=红细胞生成)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=489d3549369, createdName=许安, createdTime=Fri Jun 22 04:35:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-06-22 millore
  10. 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