Plos One:血液透析患者的甲状旁腺激素水平与死亡率的有关!

2017-03-27 MedSci MedSci原创

透析患者的死亡率高于一般人群的10至100倍。患者血清PTH的基线水平以及血清PTH近期的变化水平(ΔPTH)与透析患者的死亡率相关。近期,一项发表在杂志Plos One上的研究评估了115位具有指南推荐的中位基线iPTH水平的普通血液透析患者中,其1年的ΔPTH与未来一年的死亡率之间的关系。此项研究结果显示:中位基线iPTH水平为205(116.5,400)pg / ml。基线与1年后的ΔiPT

透析患者的死亡率高于一般人群的10至100倍。患者血清PTH的基线水平以及血清PTH近期的变化水平(ΔPTH)与透析患者的死亡率相关。

近期,一项发表在杂志Plos One上的研究评估了115位具有指南推荐的中位基线iPTH水平的普通血液透析患者中,其1年的ΔPTH与未来一年的死亡率之间的关系。

此项研究结果显示:中位基线iPTH水平为205(116.5,400)pg / ml。基线与1年后的ΔiPTH为85.2±57.1pg / ml。在随访的第二年,有27人死亡。存活患者(+157.30±25.82 pg / ml)的ΔiPTH明显高于死亡患者(+39.03±60.95 pg / ml),而这些患者的基线iPTH值无显着差异。
在ΔiPTH降低(ΔiPTH四分位数1,负ΔiPTH)的患者中死亡率最高(48%),在四分位数3ΔiPTH患者中(ΔiPTH增加101-300pg / ml)死亡率最低(12%)。

在逻辑回归模型中,ΔiPTH与死亡率相关,优势比(OR)为0.998(95%CI 0.996-0999,p = 0.038)。在多变量分析中,ΔiPTH为0-100pg / ml和101-300pg / ml患者的死亡率风险分别比具有ΔiPTH降低的患者的死亡率风险降低了73%和88%。在ΔiPTH降低的患者中,死亡OR为4.131(1.515-11.27)(p = 0.006)。

此项研究结果表明:在普通血液透析患者中,中位数基线iPTH值在指南推荐范围内,ΔiPTH的降低与死亡率升高有关。

原始出处:
Villa-Bellosta R, Rodriguez-Osorio L, et al. A decrease in intact parathyroid hormone (iPTH) levels is associated with higher mortality in prevalent hemodialysis patients. PLoS One. 2017 Mar 24;12(3):e0173831. doi: 10.1371/journal.pone.0173831. eCollection 2017.

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  4. [GetPortalCommentsPageByObjectIdResponse(id=317567, encodeId=a6f431e5674c, content=为什么平均数加减标准差.的标准差可以这么大, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJzbqY6P6WJn7XnDpciadUqibovscwF50b15lvCKDGzFl0QkGiaMZTW2TcvEVCdZeBoHNznE9hEcRUjg/132, createdBy=e0262225482, createdName=12110d58m77暂无昵称, createdTime=Tue May 22 16:56:26 CST 2018, time=2018-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789910, encodeId=58121e89910f5, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Aug 03 13:27:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998305, encodeId=ef52199830572, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Sun Dec 10 13:27:00 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192012, encodeId=937719201220, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Apr 30 06:16:15 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183575, encodeId=cb871835e5e3, content=谢谢分享,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Wed Mar 29 19:32:04 CST 2017, time=2017-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262481, encodeId=154012624819d, content=<a href='/topic/show?id=a57589339a4' target=_blank style='color:#2F92EE;'>#血液透析#</a>, beContent=null, objectType=article, channel=null, level=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183210, encodeId=461518321030, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Mar 28 07:54:07 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-04-30 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183210, encodeId=461518321030, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Mar 28 07:54:07 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-29 绛珠草小姐

    谢谢分享,学习了。

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183210, encodeId=461518321030, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Mar 28 07:54:07 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-29 habb
  7. 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  8. 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  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183210, encodeId=461518321030, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Mar 28 07:54:07 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 虈亣靌

    学习了谢谢分享

    0

  10. 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