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Thorax：CXCL14是特发性肺纤维化Hh信号的候选生物标志物！！！

2017-03-08 xing.T MedSci原创

CXCL14特发性肺纤维化Hh信号标志物
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由此可见，CXCL14是一个全身性的生物标志物，可以用来识别Hh通路活性增加的IPF患者，并且监控IPF患者进行Hh拮抗剂治疗的药效学作用。

特发性肺纤维化（IPF）与发育信号通路中分子的异常表达有关，这些分子包括Hedgehog（Hh）信号（通路）。由于Hh信号通路有助于多种促纤维化过程的发生发展，抑制Hh信号通路可能是IPF的一种治疗选择。然而，并没有非侵入性的生物标志物可用于监测肺脏Hh信号通路的活性。

近日，胸部疾病领域权威杂志Thorax上发表了一篇研究文章，研究人员检测了IPF患者和对照者肺脏活检标本、小鼠肺脏、离体培养的接受Sonic hedgehog（SHh）处理的成纤维细胞、IPF患者和对照者血浆以及接受Hh抑制剂vismodegib治疗的肿瘤患者治疗前后血浆中蛋白表达情况。

研究人员从IPF患者采集的肺组织中发现Hh相关基因的表达程度相比于对照者显著增加。而在IPF患者和离体培养的接受SHh处理的成纤维细胞中表达上调最显著的是CXCL14，该基因编码可溶性分泌趋化因子，其表达的可被体外vismodegib处理所抑制。通过小鼠肺脏过表达SHh可以诱导CXCL14的表达。IPF患者循环中CXCL14蛋白水平明显高于对照者。在癌症患者中，接受vismodegib治疗后循环CXCL14的水平明显降低。

由此可见，CXCL14是一个全身性的生物标志物，可以用来识别Hh通路活性增加的IPF患者，并且监控IPF患者进行Hh拮抗剂治疗的药效学作用。

原始出处：

Guiquan Jia, et al. CXCL14 is a candidate biomarker for Hedgehog signalling in idiopathic pulmonary fibrosis.Thorax. 2017. http://dx.doi.org/10.1136/thoraxjnl-2015-207682

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    2017-11-06 xinxin088

    #特发性#

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    2017-06-27 wetgdt

    #CXCL1#

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    2017-09-08 hukaixun

    #标志物#

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    2017-03-10 zhu_jun9842

    #生物标志#

    0

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    2017-03-10 zhu_jun9842

    #生物标志#

    0