J Oral Microbiol:牙龈卟啉单胞菌与怀孕失败之间存在关联

2017-08-02 MedSci MedSci原创

在此项观察性和前瞻性研究中,研究人员探究了牙周炎患者的牙周微生物及血清学标志物是否与妊娠相关。研究共纳入了256名非妊娠期女性(平均年龄为29.2岁,范围为19~42岁)。对其进行临床口腔和妇科检查,检测唾液中主要牙周致病菌,并分析血清和唾液中主要牙周致病菌的抗体。随访时间为这些女性开始备孕到备孕后的12个月。结果显示,与怀孕的女性(2.1%)相比,未怀孕的女性(8.3%)其唾液中牙龈卟啉单胞菌的

在此项观察性和前瞻性研究中,研究人员探究了牙周炎患者的牙周微生物及血清学标志物是否与妊娠相关。 研究共纳入了256名非妊娠期女性(平均年龄为29.2岁,范围为19~42岁)。对其进行临床口腔和妇科检查,检测唾液中主要牙周致病菌,并分析血清和唾液中主要牙周致病菌的抗体。随访时间为这些女性开始备孕到备孕后的12个月。 结果显示,与怀孕的女性(2.1%)相比,未怀孕的女性(8.3%)其唾液中牙龈卟啉单胞菌的检出率明显升高(P = 0.032)。未怀孕女性唾液中牙龈卟啉单胞菌免疫球蛋白A(IgA;P = 0.006)和IgG抗体水平的中位数均高于那些怀孕的女性(P = 0.007)。未怀孕的危险比(HR)为HR为3.75(95%可信区间[CI] 1.01-13.9;P = 0.048),若未怀孕女性牙龈卟啉单胞菌聚合酶链反应阳性,唾液中抗体水平较高,则HR = 3.75 (95% CI 1.01–13.9; p = 0.048),若其血清牙龈卟啉单胞菌IgA水平较高,则HR = 1.62(95% CI 1.03-2.54;P = 0.035)。 总而言之,该研究表明,牙龈卟啉单胞菌与怀孕

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    2018-03-29 智智灵药
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    2018-04-16 小几洁
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    2018-05-10 xjy02
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    2017-08-03 1861f6de06m

    学习

    0

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    2017-08-03 狼毒花1982

    学习了感谢分享

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