Lancet Oncol：非透明细胞肾癌：舒尼替尼 vs 依维莫司

2016-02-21 Mechront 译 MedSci原创

研究者对非透明细胞肾癌患者进行了一项多中心的Ⅱ期临床试验研究，比较mTOR抑制剂依维莫司和血管内皮生长因子受体抑制剂舒尼替尼的疗效。研究纳入了2010年9月23日至2013年10月28日间108名既往未接受全身治疗的转移性乳头状肾细胞癌、嫌色细胞肾癌或未分化癌患者，按1:1随机分为依维莫司组（10 mg/天）（N = 51）和舒尼替尼（50 mg/天，6周一个周期，4周给药后停止2周）（N =

研究者对非透明细胞肾癌患者进行了一项多中心的Ⅱ期临床试验研究，比较mTOR抑制剂依维莫司和血管内皮生长因子受体抑制剂舒尼替尼的疗效。

研究纳入了2010年9月23日至2013年10月28日间108名既往未接受全身治疗的转移性乳头状肾细胞癌、嫌色细胞肾癌或未分化癌患者，按1:1随机分为依维莫司组（10 mg/天）（N = 51）和舒尼替尼（50 mg/天，6周一个周期，4周给药后停止2周）（N = 57），直到疾病进展或不可接受的毒性反应时停止服药。

研究数据显示，舒尼替尼与依维莫司相比，可显著延长患者无进展生存期(8.3 个月 [80% CI 5.8-11.4] vs 5.6 个月[80% CI 5.5–6.0]；HR=1.41[80% CI 1.03-1.92]；P = 0.16)。研究期间没有出现特殊不良反应，舒尼替尼与依维莫司组最常见的3-4级不良事件包括高血压(12/51[24%] vs 1/57[2%])、感染（6[12%] vs 4[7%]）、腹泻（5[10%] vs 1[2%]）、肺炎（0 vs 5[9%]）、口腔炎（0 vs 5[9%]）、手足综合征（4[8%] vs 0）。

研究结果表明，舒尼替尼与依维莫司相比，可显著延长转移性非透明细胞肾癌患者无进展生存期。以后的研究将考虑到不同基因分型、组织分型和预后因素可能会导致不同治疗效果的异质性。

原始出处：

Armstrong AJ, Halabi S,et al.Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial.Lancet Oncol. 2016 Jan 12. pii: S1470-2045(15)00515-X. doi: 10.1016/S1470-2045(15)00515-X.

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2016-10-15 1e10c84am36(暂无匿称)

好文章，赞

68 0
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2016-09-08 howi

#Lancet#

24 0
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2016-08-26 minlingfeng

#Oncol#

31 0
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2016-03-30 忠诚向上

好好学习一下

107 0
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2016-03-30 忠诚向上

好好学习一下

97 0
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2016-03-30 忠诚向上

好好学习一下

92 0
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2016-03-30 忠诚向上

好好学习一下

78 0
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2016-03-30 忠诚向上

好好学习一下

76 0
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2016-03-30 忠诚向上

好好学习一下

38 0
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2016-03-30 忠诚向上

好好学习一下

95 0

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