KIDNEY INT:晚期慢性肾脏病患者感染导致心血管事件和死亡率风险增加

2016-09-27 xing.T MedSci原创

因此,研究结果表明慢性肾脏病患者容易发生感染,而且一旦感染发生与随后的不良预后存在密切的相关性。

晚期慢性肾脏疾病患者感染的风险以及感染引起的对后续的不良预后的影响尚不明了。近日,肾脏病领域权威杂志《kidney international》上发表加拿大不列颠哥伦比亚大学肾病科Hassan医生及其团队的文章,旨在确定晚期慢性肾脏疾病(估计肾小球滤过率为15–45 ml/min/1.73m2)患者发生感染与后续的心血管缺血、充血性心脏衰竭、终末期肾脏疾病或死亡率之间的关系。

研究者纳入参与了加拿大的前瞻性队列研究中的晚期慢性肾脏病患者,他们被肾脏科医师随访长达5年。感染性发作的根据解剖位置进行分类,并通过阳性培养进行病原体鉴定、住院和抗生素使用来确认感染发生。竞争风险模型被用来研究随时间变化的感染风险和心血管缺血、充血性心脏衰竭、或终末期肾脏疾病及死亡率的关系。


在2370例慢性肾脏病患者(平均年龄68岁;平均估计基础肾小球滤过率为28.2 ml/min/1.73m2)中,575例(24.3%)患者有感染发生,378例患者发生过1次感染,而197例患者发生过2次或更多次数的感染,最常见的是泌尿系统和呼吸系统感染。感染事件与心血管缺血(危险比1.80,95%置信区间1.24–2.60)、充血性心力衰竭(危险比3.2,95%置信区间2.25–4.61)、终末期肾脏疾病(危险比,1.58,95%置信区间1.22–2.05)和死亡率(危险比3.39,置信区间2.65–4.33)风险增加存在独立相关性。

因此,研究结果表明慢性肾脏病患者容易发生感染,而且一旦感染发生与随后的不良预后存在密切的相关性。

原始出处:

Hicham I. Cheikh Hassan, et al. Infection in advanced chronic kidney disease leads to increased risk of cardiovascular events, end-stage kidney disease and mortality. kidney international.2016.  

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1643425, encodeId=781f164342538, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Mon Mar 27 10:34:00 CST 2017, time=2017-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=147764, encodeId=bfe414e7642f, content=文章真好,喜欢阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 13 14:47:36 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144356, encodeId=5d811443561d, content=好文章,长见识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Oct 11 15:01:53 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138220, encodeId=6bb113822011, content=手术后预防感染很关键!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Fri Sep 30 17:31:26 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138218, encodeId=66c4138218a1, content=学习了,分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Fri Sep 30 17:30:53 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602963, encodeId=9a351602963e0, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Thu Sep 29 11:34:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616076, encodeId=5d8916160e66c, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Thu Sep 29 11:34:00 CST 2016, time=2016-09-29, status=1, ipAttribution=)]
    2016-10-13 1e10c84am36(暂无匿称)

    文章真好,喜欢阅读

    0

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,长见识

    0

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    2016-09-30 1e0d99ddm02(暂无匿称)

    手术后预防感染很关键!

    0

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    2016-09-30 1e0d99ddm02(暂无匿称)

    学习了,分享一下!

    0

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    2016-09-29 gwc389
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