Eur Heart J-Card Img:静息时右心室功能与PAH患者运动表现相关!

2018-02-11 xing.T MedSci原创

由此可见,在PAH患者中,由FAC或RVLS评估的静息RV功能与患者运动表现相关,因此对PAH患者的非侵入性评估具有重大贡献。在CTEPH患者中未发现这种关联,提示静息右心室功能与运动表现之间无关,无法将运动指标作为CTEPH患者的预后标记和临床/研究终点。

近日,心血管领域权威杂志Eur Heart J-Card Img上发表了一篇研究文章,该研究旨在评估经全身RV纵向应变(RVLS)和RV分数面积变化(FAC)确定的静息时右心室(RV)功能是否与肺动脉高压(PAH)和慢性血栓栓塞性肺动脉高压(CTEPH)患者的运动表现相关。

研究人员前瞻性地招募了连续就诊的46例PAH患者和42例CTEPH患者,这些患者接受了心肺运动试验(CPET)和经胸超声心动图检查。采用RVLS和FAC进行静息RV收缩功能评估。所分析的CPET参数为预测的最大耗氧量(VO2max)百分比和通气与二氧化碳产生比值的斜率(VE/VCO2)。研究人员对超声心动图指标与CPET指标之间进行Spearman相关性检验。

在PAH患者中,Spearman相关性检验发现RVLS与VE/VCO2(系数=0.556,P<0.001)和预测的VO2max百分比(系数=-0.393,P=0.007)之间存在相关性,而FAC与VE/VCO2(系数=0.481,P=0.001)和预测的VO2max百分比(系数=0.356,P=0.015)相关。相反,在CTEPH患者中,静息的RV功能与预测的VO2max百分比和VE/VCO2无关,无论是通过RVLS还是FAC来评估。

由此可见,在PAH患者中,由FAC或RVLS评估的静息RV功能与患者运动表现相关,因此对PAH患者的非侵入性评估具有重大贡献。在CTEPH患者中未发现这种关联,提示静息右心室功能与运动表现之间无关,无法将运动指标作为CTEPH患者的预后标记和临床/研究终点。

原始出处:

Michaela Beatrice Rehman,et al. Resting right ventricular function is associated with exercise performance in PAH, but not in CTEPH. Eur Heart J-Card Img. 2018. https://doi.org/10.1093/ehjci/jex002

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1935826, encodeId=345e193582696, content=<a href='/topic/show?id=39b5386288c' target=_blank style='color:#2F92EE;'>#右心室功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38628, encryptionId=39b5386288c, topicName=右心室功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Feb 26 08:21:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287838, encodeId=2e7828e838aa, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Wed Feb 14 09:04:33 CST 2018, time=2018-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356686, encodeId=11f1135668665, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 13 04:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460192, encodeId=058d146019235, content=<a href='/topic/show?id=1519136e641' target=_blank style='color:#2F92EE;'>#PAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13676, encryptionId=1519136e641, topicName=PAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87966261195, createdName=hb2010ye, createdTime=Tue Feb 13 04:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543749, encodeId=34881543e4972, content=<a href='/topic/show?id=52d93862e06' target=_blank style='color:#2F92EE;'>#右心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38627, encryptionId=52d93862e06, topicName=右心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18d13610637, createdName=124988c7m99暂无昵称, createdTime=Tue Feb 13 04:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562831, encodeId=016f156283189, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Feb 13 04:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-14 139****5926

    好好文章学习了

    0

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    2018-02-13 zhaojie88
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    2018-02-13 hb2010ye
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    2018-02-13 slcumt

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