Medicine:ICU患者行支气管镜检查,到底该用右美托咪定还是咪达唑仑?

2017-06-30 MedSci MedSci原创

本研究旨在探讨对需要接受纤维支气管镜检查的重症监护室(ICU)患者来说患者来说,右美托咪啶和咪达唑仑的镇静效果有何不同。

本研究旨在探讨对需要接受纤维支气管镜检查的重症监护室(ICU)患者来说,右美托咪啶和咪达唑仑的镇静效果有何不同。

这项回顾性队列研究的对象为2012年3月到2014年12月之间,哈尔滨医科大学附属第二医院3个ICU病房里的148例接受有创机械通气和接受纤维支气管镜检查的重症患者。根据镇静药物不同,患者被随机分为右美托咪定组(n = 72)和咪达唑仑组(n = 76)。对镇静效果、不良事件的发生率及支气管镜检查者满意度评分进行组间比较。

在对患者行支气管检查中,咪达唑仑组接受镇静的总时间和行支气管镜的总时间明显缩短(P<0.001),需要补救性加用丙泊酚的患者百分率也较小(P<0.001)。

关于支气管镜检查的不良事件发生率(包括支气管痉挛、咳嗽和血氧饱和度下降),右美托咪啶组明显高于咪达唑仑组。然而,各组间其他不良事件的发生率没有显著差异。此外,咪达唑仑组支气管镜检查者的满意度评分均明显高于右美托咪定组(7.72±1.65 vs 7.08±1.77;P =0.030)。

从而我们得出结论:对ICU患者实施纤维支气管镜检查时,与单用右美托咪定相比,联合咪达唑仑组镇静效果较好、不良事件发生率较低、支气管镜检查者的满意度较高。因此,对于实施纤维支气管镜的ICU患者来说咪达唑仑不失为一个合适的选择。

原始出处:

Gao Y1, Kang K, Liu H,et al. Effect of dexmedetomidine and midazolam for flexible fiberoptic bronchoscopy in intensive care unit patients: A retrospective study. Medicine (Baltimore). 2017 Jun;96(25):e7090. doi: 10.1097/MD.0000000000007090.

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    2018-03-10 kalseyzl
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  5. 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content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Sun Jul 02 10:37:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607771, encodeId=37d2160e77192, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jul 02 10:37:00 CST 2017, time=2017-07-02, status=1, ipAttribution=)]
    2017-08-09 jeanqiuqiu
  6. 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