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研究性反义寡核苷酸疗法AKCEA-ANGPTL3-LRx治疗高甘油三酯血症取得阶段进展

2020-01-29 Allan MedSci原创

高甘油三酯血症AKCEA-ANGPTL3-LRx反义寡核苷酸疗法
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Ionis制药公司和Akcea制药公司今日公布了AKCEA-ANGPTL3-LRx治疗高甘油三酯血症、2型糖尿病和非酒精性脂肪肝病（NAFLD）的II期研究的阳性结果。

Ionis制药公司和Akcea制药公司今日公布了AKCEA-ANGPTL3-LRx治疗高甘油三酯血症、2型糖尿病和非酒精性脂肪肝病（NAFLD）的II期研究的阳性结果。该研究达到了显著降低甘油三酯的主要终点，并具有良好的安全性和耐受性特征。AKCEA-ANGPTL3-LRx是一种研究性反义寡核苷酸疗法，正在开发用于某些心血管和代谢疾病。

II期研究的目的是评估AKCEA-ANGPTL3-LRx的安全性和有效性。这项多中心、随机、双盲、安慰剂对照研究招募了105例高甘油三酸酯血症、2型糖尿病和NAFLD患者。通过皮下注射施用AKCEA-ANGPTL3-LRx或安慰剂，为期六个月。


原始出处：

https://www.firstwordpharma.com/node/1696788

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    2020-02-01 flyingeagle85

    #高甘油三酯#

    0

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    2020-03-26 qingrejiedu

    #Akcea#

    0

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-27 whmdzju

    #反义寡核苷酸疗法#

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Wed Apr 08 06:17:01 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381423, encodeId=42d138142300, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Tue Apr 07 08:11:08 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381422, encodeId=856638142297, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Tue Apr 07 08:10:58 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381406, encodeId=df7a3814065a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Mon Apr 06 21:22:49 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381307, encodeId=86a538130e89, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Apr 04 00:21:35 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381246, encodeId=0849381246e3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Thu Apr 02 07:28:48 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-08 sam2000jie

    学习

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Tue Apr 07 08:10:58 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381406, encodeId=df7a3814065a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Mon Apr 06 21:22:49 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381307, encodeId=86a538130e89, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Apr 04 00:21:35 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381246, encodeId=0849381246e3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Thu Apr 02 07:28:48 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-07 sam2000jie

    学习

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Tue Apr 07 08:10:58 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381406, encodeId=df7a3814065a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Mon Apr 06 21:22:49 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381307, encodeId=86a538130e89, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Apr 04 00:21:35 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381246, encodeId=0849381246e3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Thu Apr 02 07:28:48 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-07 sam2000jie

    学习

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Wed Apr 08 06:17:01 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381423, encodeId=42d138142300, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Tue Apr 07 08:11:08 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381422, encodeId=856638142297, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Tue Apr 07 08:10:58 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381406, encodeId=df7a3814065a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Mon Apr 06 21:22:49 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381307, encodeId=86a538130e89, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Apr 04 00:21:35 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381246, encodeId=0849381246e3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Thu Apr 02 07:28:48 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-06 sam2000jie

    学习了

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Apr 04 00:21:35 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381246, encodeId=0849381246e3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Thu Apr 02 07:28:48 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-04 sam2000jie

    学习了

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Apr 04 00:21:35 CST 2020, time=2020-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381246, encodeId=0849381246e3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Thu Apr 02 07:28:48 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=381058, encodeId=12c9381058a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3Xj3dPpicVeGMtJVVf6ictxZkIbnfAicknI9T9Sic1GH3tiaC7Dl2R75mclpwGRcAaPicKInqB6mgfsTCCaicqGwWg49X/0, createdBy=4a7623908, createdName=sam2000jie, createdTime=Sat Mar 28 06:02:07 CST 2020, time=2020-03-28, status=1, ipAttribution=)]
    2020-04-02 sam2000jie

    学习了

    0

  10. 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    2020-03-28 sam2000jie

    学习了

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