Aalzheimer & Dementia:吃什么很重要——“炎症饮食”与大脑老化密切相关

2022-05-15 MedSci原创 MedSci原创

饮食结构的确与慢性低度炎症息息相关。

饮食结构的确与慢性低度炎症息息相关。人每天吃饭,肠道在代谢过程中,就会产生炎性递质。如果摄入高油脂和高脂肪的食物,炎性递质就会过度表达,进而导致炎症出现。但有些物质,比如ω-3多不饱和脂肪酸,就可以抑制前列腺环氧化酶的表达,具有抗炎作用。

研究显示,富含饱和脂肪、糖、盐等纤维水平较低的食物在进入肠道后,可诱发炎症和自身免疫反应,这类食物被称为“促炎食物”。而有些食物能改善人体中的炎性生物标志物水平,有助于减轻人体炎症,因此被称为“抗炎食物”。

近期,来自美国的学者调查了弗雷明汉心脏研究后代队列参与者的饮食炎症指数(DII)与脑容量和脑小血管疾病措施之间的横断面关联,结果发表在Alzheimer&Dementia杂志上。结果共有1897名参与者(平均±标准差,年龄62±9岁)完成了食物频率调查表和脑磁共振成像(MRI)。

结果显示,在调整了人口统计学、临床和生活方式等协变量后,较高的(促炎症)DII得分,在最多三个时间点上的平均值,与较小的总脑体积有关(β±标准误差:-0.16±0.03;P<0.0001)。此外,较高的DII分数与较小的总灰质体积(-0.08 ± 0.03; P = .003)和较大的侧脑室体积(0.04 ± 0.02; P = .03)有关。没有观察到与其他脑MRI指标的关联。

该研究结果显示,较高的DII分数与全脑MRI指标之间存在关联。由于该研究是第一批报告较高的DII分数和脑容量之间关系的小组之一,因此需要重复研究以证实上述发现。

 

参考文献:

Higher Dietary Inflammatory Index scores are associated with brain MRI markers of brain aging: Results from the Framingham Heart Study Offspring cohort. https://doi.org/10.1002/alz.12685

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    2023-09-03 mzeng1 来自云南省

    学无止境!感谢作者🌹🤝

    0

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    2023-06-21 513828430 来自福建省

    吃健康食品,地中海饮食吗

    0

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    2022-05-15 xulv123

    认真学习~~

    0

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