JAMA Pediatr:青少年酒精综合征的全球发病率

2017-08-22 海北 MedSci原创

胎儿酒精综合征发病率的估计对于有效优先,有计划性地为高需求群体提供卫生医疗保健至关重要。但是,至今为止,大部分国家并没有胎儿酒精综合征的流行病学数据。来自加拿大的研究人员通过国家,世界卫生组织,和全球范围,获得了一般人群中儿童和青少年患有胎儿酒精综合征的几率。

胎儿酒精综合征发病率的估计对于有效优先,有计划性地为高需求群体提供卫生医疗保健至关重要。但是,至今为止,大部分国家并没有胎儿酒精综合征的流行病学数据。来自加拿大的研究人员通过国家,世界卫生组织,和全球范围,获得了一般人群中儿童和青少年患有胎儿酒精综合征的几率。

研究人员在MEDLINE,MEDLINE在线,EMBASE,教育资源信息中心,护理和联合健康文献累积指数,Web of Science,PsychINFO和Scopus上系统地搜索了从1973年11月1日至2015年6月30日发布的研究报告。研究报告没有地理或语言限制。

研究人员提取了各个研究中胎儿酒精综合征的特征和流行率,并进行了国家特异性随机荟萃分析。对于只有一个研究或是没有相关研究的国家,其胎儿酒精综合征发病率是通过怀孕期间妇女饮酒的比例估计的。最后,胎儿酒精综合征在世卫组织区域和全球的发病率是通过每个国家新生儿的数量进行加权的。

最终,研究人员保留了24项研究,包括了1416名被诊断患有胎儿酒精综合征的儿童和青少年(年龄范围0-16.4岁),并进行数据提取。在全球普通人群中,胎儿酒精综合征的发病率估计为每1000人口7.7人(95%CI,每1000人口4.9-11.7人)。世界卫生组织欧洲地区的发病率最高(每1000人口为19.8人; 95%CI,每1000人口为14.1-28.0)。世卫组织东地中海区域最低(每1000人口为0.1人; 95%CI,每1000人口为0.1-0.5)。而在全球187个国家中,南非的胎儿酒精综合征发病率最高,每1000人口为111.1人(95%CI,每1000人口为71.1-158.4)。其次为克罗地亚,每1000人口为53.3人(95%CI,每1000人口为30.9-81.2),和爱尔兰,每1000人口为47.5人(95%CI,每1000人口为28.0-73.6)。

在全球范围内,胎儿酒精综合征是一种和酒精相关的发育障碍,在很大程度上是可以预防的。调查结果显示,我们需要建立一个关于产前酒精暴露潜在危害和常规检查方案的通用公共卫生信息,并酌情给予适当的干预措施。


原始出处:

Shannon Lange et al. Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysisJAMA Pediatrics, August 2017 DOI: 10.1001/jamapediatrics.2017.1919


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    2018-06-17 feather89
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    2017-08-22 lyh994

    很大程度上是可以预防的

    0

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    2017-08-22 执着追梦

    学习.谢谢分享

    0

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    2017-08-22 李东泽

    很好.不错.以后会多学习

    0