Radiology:精神分裂症患者灰质在减少

2018-02-18 shaosai MedSci原创

本研究旨在验证精神分裂症患者结构变化的空间及因果关系,并将结果发表在radiology上。

本研究旨在验证精神分裂症患者结构变化的空间及因果关系,并将结果发表在radiology上。

本研究共纳入了97例精神分裂症患者(女性29例,平均年龄41岁 ± 11.5;范围16-66 岁; 病程16.3 岁 ± 10.9; 范围0-50 岁)及126例性别和年龄匹配的健康志愿者(38岁±14.9;范围18-68岁; 女性42例)。利用结构变化的因果网络评价精神分裂症患者结构变化的因果关系。根据病程进行分级,并利用格兰杰因果关系分析T1加权图像。

结果为,随着病程的延长,丘脑灰质体积逐渐减小并累及到额叶,然后是颞叶、枕叶皮层及小脑(P < .00001)。结果显示丘脑是方位网络的中心并对额叶、颞叶、枕叶及小脑具有正性因果影响(P < .05)。额叶作为交接点,向枕叶、颞叶和小脑区域传递因果影响并接受丘脑产生的因果影响。

本研究表明,精神分裂症会出现进行性灰质异常,以丘脑为原发中心、额叶为节点。

原始出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=289239, encodeId=caf628923942, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Feb 19 21:05:55 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404084, encodeId=2aba14040840f, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Mon Feb 19 16:04:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288828, encodeId=43b42888280e, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 18 07:20:13 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288795, encodeId=55c7288e95da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Feb 18 03:26:43 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288789, encodeId=3820288e898c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Feb 18 03:23:12 CST 2018, time=2018-02-18, status=1, ipAttribution=)]
    2018-02-19 虈亣靌

    签到学习了--

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=289239, encodeId=caf628923942, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Feb 19 21:05:55 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404084, encodeId=2aba14040840f, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Mon Feb 19 16:04:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288828, encodeId=43b42888280e, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 18 07:20:13 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288795, encodeId=55c7288e95da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Feb 18 03:26:43 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288789, encodeId=3820288e898c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Feb 18 03:23:12 CST 2018, time=2018-02-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=289239, encodeId=caf628923942, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Feb 19 21:05:55 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404084, encodeId=2aba14040840f, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Mon Feb 19 16:04:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288828, encodeId=43b42888280e, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 18 07:20:13 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288795, encodeId=55c7288e95da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Feb 18 03:26:43 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288789, encodeId=3820288e898c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Feb 18 03:23:12 CST 2018, time=2018-02-18, status=1, ipAttribution=)]
    2018-02-18 Drhzm308

    谢谢.学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=289239, encodeId=caf628923942, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Feb 19 21:05:55 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404084, encodeId=2aba14040840f, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Mon Feb 19 16:04:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288828, encodeId=43b42888280e, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 18 07:20:13 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288795, encodeId=55c7288e95da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Feb 18 03:26:43 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288789, encodeId=3820288e898c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Feb 18 03:23:12 CST 2018, time=2018-02-18, status=1, ipAttribution=)]
    2018-02-18 121832a9m88暂无昵称

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=289239, encodeId=caf628923942, content=签到学习了--, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Feb 19 21:05:55 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404084, encodeId=2aba14040840f, content=<a href='/topic/show?id=7366e6493be' target=_blank style='color:#2F92EE;'>#精神分裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76493, encryptionId=7366e6493be, topicName=精神分裂)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIXE1PadWxBeosSHpB06cC9uZflHWBnMib5rSPbq29kzxyzUPEqWfvlNl0DMmX9070Gdwbq4zwg4vg/132, createdBy=bfe92444551, createdName=bnurmamat, createdTime=Mon Feb 19 16:04:00 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288828, encodeId=43b42888280e, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 18 07:20:13 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288795, encodeId=55c7288e95da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Feb 18 03:26:43 CST 2018, time=2018-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288789, encodeId=3820288e898c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Feb 18 03:23:12 CST 2018, time=2018-02-18, status=1, ipAttribution=)]
    2018-02-18 秀红

    学习了

    0

相关资讯

Schizophr Bull:如何用生物标记物介导精神分裂症治疗?

所有FDA批准的治疗精神分裂症的抗精神病药都拮抗多巴胺D2受体,因此需要找到新型精神分裂症治疗靶点。最近研究表明,氧化应激,特别是谷胱甘肽(GSH)系统的缺陷,在精神分裂症的病理生理中起作用。

JAMA psychia:新的研究工具可能会降低精神分裂症药物的研发风险

哥伦比亚大学医学中心(CUMC)和纽约州精神病研究所(NYSPI)的研究人员已经确定了可以帮助开发更好的精神分裂症治疗的生物标志物。该研究结果在线发表在JAMA Psychiatry上。

Transl Psychiatry:初步研究表明视频游戏可能是精神分裂症患者的一个有效疗法

据外媒 Techspot 报道,伦敦国王学院精神病学、心理学和神经科学研究所(IoPPN)和罗汉普顿大学的科学家们刚刚完成了一项“试点”研究,这可能可以教精神分裂症患者如何控制他们的言语幻觉。

Hum Brain Mapp:运动协调与感觉整合背后的脑激活是可遗传的

越来越多的研究显示神经软体征(neurological soft signs,NSS)是精神分裂症谱系疾病可靠的内表型之一。尽管已有神经影像学研究从不同程度揭示了神经软体征中运动协调与去抑制这两个成分的大脑网络,而另一个成分感觉整合的神经机制尚不明晰。中国科学院心理健康重点实验室神经心理学与应用认知神经科学(NACN)实验室的陈楚侨研究员及其团队成员从行为层面上估算了神经软体征的遗传度与家族度,然

Lancet Psychiat:重磅!“阿凡达疗法”有望治愈精神分裂症,12周幻听消失!

一项英国试验发现,面对电脑屏幕上的化身,有助于患者更好地应付幻觉。接受这种疗法的精神分裂症患者变得不那么痛苦,听到的声音比其他患者更少了。

Transl Psychiat:新证据:精神分裂症起始时间更早,孕早期就有异样!

一项新的研究发现,精神分裂症可能在怀孕前12周就开始出现,这意味着可以在出生前就对其进行治疗。