盘点:2018年5月12日Lancet研究精选

2018-05-11 zhangfan MedSci原创

2018年5月12日Lancet研究精选



【1】封面文章--基于新西兰初级医疗保健人群队列的心血管疾病风险预测模型


大多数心血管疾病风险预测模型建立于上个世纪,其队列参与者年龄较高,疾病风险较大,并且关于社会、经济和种族等因素的考察不全面。近日研究人员对新西兰初级保健人群的心血管疾病风险进行模型预测,并比较其与美国人口疾病预测模型(PCES)的差异。

401752名年龄30-74岁志愿者参与研究,平均随访4.2年,其中15386名患者(4%)发生心血管事件,其中致命性事件1507起,动脉粥样硬化性心血管疾病8549起。男女人群5年的总心血管事件发生率为3.2%和2.3%。多因素模型发现,最贫困1/5人群的心血管风险增加10%;毛利族、太平洋裔以及印第安裔人群的心血管疾病风险较欧洲、华裔以及其他亚裔人群高13-48%;亚裔人群较欧洲人群的心血管风险低25-33%。新预测模型所有性能指标优于PCEs。

【2】撒哈拉以南非洲霍乱疫情负担研究


霍乱仍然是撒哈拉以南非洲和世界范围内持续存在的健康问题。目前霍乱的防治可通过水、公共卫生控制以及霍乱疫苗等方法。近日研究人员对撒哈拉以南非洲的霍乱负担进行考察并评估更有效的干预措施。

研究包含279个数据集,覆盖2283个地点。在撒哈拉以南非洲,每年的霍乱疫情发病141918例,4.0%的地区,约8700万人口生活在霍乱高发疫区。研究认为以高发区为重点,采取有效的针对性干预措施,可消除该地区50%的霍乱,总计受益人口为3530万。

【3】新方法可有效降低东南亚地区恶性疟流行


恶性疟原虫疟疾仍是大湄公河区域的重要公共卫生难题。近日研究人员考察了恶性疟原虫疟疾的早期诊断、治疗及定向大量给药对该地区疟疾的预防效果。

365000名参与者中1222人接受早期诊断及治疗,疫区恶性疟原虫发病率下降了60-98%。研究期间总计进行272次流行病学调查,确定69个村庄为疫区热点地区,其发病率约是其他地区的2.7倍,其中50个热点地区接受大剂量药物治疗。早期诊断及治疗可显著降低热点地区的发病率,效果优于平均水平。大剂量治疗可5倍以上降低热点地区的疟疾发病率。截止2017年4月,79%的村庄实现至少6个月以上无恶性疟发病。研究期间青蒿素抗性K13分子标记野生型基因流行率稳定(39%;249/631)。

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    2019-04-11 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1829621, encodeId=f043182962194, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 11 09:51:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314512, encodeId=2a2d3145120f, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Sat May 12 21:36:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314293, encodeId=ff2231429343, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat May 12 04:48:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314286, encodeId=991e314286fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat May 12 04:35:07 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314282, encodeId=99d0314282a8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat May 12 02:17:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314159, encodeId=e7443141591a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Fri May 11 13:55:43 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-12 cscdliu

    学习了.谢谢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1829621, encodeId=f043182962194, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 11 09:51:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314512, encodeId=2a2d3145120f, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Sat May 12 21:36:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314293, encodeId=ff2231429343, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat May 12 04:48:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314286, encodeId=991e314286fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat May 12 04:35:07 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314282, encodeId=99d0314282a8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat May 12 02:17:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314159, encodeId=e7443141591a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Fri May 11 13:55:43 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-12 121832a9m88暂无昵称

    学习了

    0

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    2018-05-12 秀红

    学习了

    0

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    2018-05-12 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1829621, encodeId=f043182962194, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 11 09:51:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314512, encodeId=2a2d3145120f, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Sat May 12 21:36:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314293, encodeId=ff2231429343, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat May 12 04:48:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314286, encodeId=991e314286fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat May 12 04:35:07 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314282, encodeId=99d0314282a8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat May 12 02:17:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314159, encodeId=e7443141591a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Fri May 11 13:55:43 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-11 zdvfsadb

    学习了

    0

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